To the Editor: Genome-wide, targeted loss-of-function pooled screens using the clustered,
regularly interspaced, short palindromic repeats (CRISPR)-associated nuclease Cas9 in …

The simplicity of programming the CRISPR (clustered regularly interspaced short palindromic
repeats)–associated nuclease Cas9 to modify specific genomic loci suggests a new way to …

Forward genetic screens are powerful tools for the discovery and functional annotation of
genetic elements. Recently, the RNA-guided CRISPR (clustered regularly interspaced short …

N6-methyladenosine (m6A) is a common modification of mRNA with potential roles in fine-tuning
the RNA life cycle. Here, we identify a dense network of proteins interacting with …

Forward genetic screens are powerful tools for the unbiased discovery and functional
characterization of specific genetic elements associated with a phenotype of interest. Recently, the …

Genetic screens are powerful tools for identifying genes responsible for diverse phenotypes.
Here we describe a genome-wide CRISPR/Cas9-mediated loss-of-function screen in tumor …

Transcription activator-like effectors (TALEs) are a class of naturally occurring DNA-binding
proteins found in the plant pathogen Xanthomonas sp. The DNA-binding domain of each …

Over the past decade, CRISPR has become as much a verb as it is an acronym, transforming
biomedical research and providing entirely new approaches for dissecting all facets of cell …

… We thank the entire Sanjana and tenOever laboratories for support and advice. We also
thank the New York Genome Center for flow cytometry and confocal microscopy resources and T…

Enhancers, critical determinants of cellular identity, are commonly recognized by correlative
chromatin marks and gain-of-function potential, although only loss-of-function studies can …