The expression of genes is regularly characterized with respect to how much, how fast, when
and where. Such quantitative data demands quantitative models. Thermodynamic models …

With the increasing amount of experimental data on gene expression and regulation, there
is a growing need for quantitative models to describe the data and relate them to their …

… (NE Buchler et al. unpublished data). Further, recent work shows that fungi and metazoans
(collectively, the ‘opisthokonts’) share a more recent LCA relative to all other eukaryotic …

Cells receive a wide variety of cellular and environmental signals, which are often processed
combinatorially to generate specific genetic responses. Here we explore theoretically the …

Protein sequestration occurs when an active protein is sequestered by a repressor into an
inactive complex. Using mathematical and computational modeling, we show how this …

Ultrasensitive responses are crucial for cellular regulation. Protein sequestration, where an
active protein is bound in an inactive complex by an inhibitor, can potentially generate …

Recent studies have shown that in addition to the transcriptional circadian clock, many
organisms, including Arabidopsis, have a circadian redox rhythm driven by the organism’s …

During bacterial growth, a cell approximately doubles in size before division, after which it
splits into two daughter cells. This process is subjected to the inherent perturbations of cellular …

The functions of most genetic circuits require a sufficient degree of cooperativity in the circuit
components. Although mechanisms of cooperativity have been studied most extensively in …

Most of the described species in kingdom Fungi are contained in two phyla, the Ascomycota
and the Basidiomycota (subkingdom Dikarya). As a result, our understanding of the biology …