Publisher Summary This chapter presents an overview of the theoretical aspects of the “new
view” of protein folding based on the energy landscape theory and the funnel concept. The …

We describe the landscape of somatic genomic alterations based on multidimensional and
comprehensive characterization of more than 500 glioblastoma tumors (GBMs). We identify …

MicroRNAs (miRNAs) are small noncoding regulatory RNAs that reduce stability and/or
translation of fully or partially sequence-complementary target mRNAs. In order to identify …

Annotation of prostate cancer genomes provides a foundation for discoveries that can
impact disease understanding and treatment. Concordant assessment of DNA copy number, …

… Here we illustrate this kind of discussion by focusing on some recent results of Socci and
Onuchic which find evidence for specific features arising from energy landscape analysis.” In …

Background Acute myeloid leukemia (AML) is a heterogeneous disease with respect to
presentation and clinical outcome. The prognostic value of recently identified somatic mutations …

Purpose Treatment of advanced non–small-cell lung cancer with immune checkpoint inhibitors
(ICIs) is characterized by durable responses and improved survival in a subset of patients…

Background . Bacteremia is a frequent complication of allogeneic hematopoietic stem cell
transplantation (allo-HSCT). It is unclear whether changes in the intestinal microbiota during …

Leptin elicits a metabolic response that cannot be explained by its anorectic effects alone.
To examine the mechanism underlying leptin's metabolic actions, we used transcription …

Bloodstream infection by highly antibiotic-resistant bacteria, such as vancomycin-resistant
Enterococcus (VRE), is a growing clinical problem that increasingly defies medical intervention…