… of the SHADOW PRICES of the two fluxes that are being examined. A shadow price is the rate
… The shadow price structure is finite in number, dividing the plane formed by the flux levels …

Genome sequencing and annotation has enabled the reconstruction of genome-scale
metabolic networks. The phenotypic functions that these networks allow for can be defined and …

Network-based definitions of biochemical pathways have emerged in recent years. These
pathway definitions insist on the balanced use of a whole network of biochemical reactions. …

Post-acute sequelae of COVID-19 (PASC) represent an emerging global crisis. However,
quantifiable risk factors for PASC and their biological associations are poorly resolved. We …

Investigators have long suspected that pathogenic microbes might contribute to the onset
and progression of Alzheimer's disease (AD) although definitive evidence has not been …

We present an integrated analysis of the clinical measurements, immune cells, and plasma
multi-omics of 139 COVID-19 patients representing all levels of disease severity, from serial …

Variation in the human gut microbiome can reflect host lifestyle and behaviors and influence
disease biomarker levels in the blood. Understanding the relationships between gut …

Multiple models of human metabolism have been reconstructed, but each represents only a
subset of our knowledge. Here we describe Recon 2, a community-driven, consensus '…

We identified rare coding variants associated with Alzheimer's disease in a three-stage case–control
study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-…

Anti-inflammatory strategies are proposed to have beneficial effects in Alzheimer's disease.
To explore how anti-inflammatory cytokine signaling affects Aβ pathology, we investigated …