Vaginal Discharge

LM Torres-Deas, NC Habibe Burgos… - Handbook of Outpatient …, 2023 - Springer
Vaginal discharge accounts for almost ten million annual visits to primary care clinics in the
United States. Although most commonly physiological, it may be a symptom of an underlying …

Single-chromosome aneuploidy commonly functions as a tumor suppressor

JM Sheltzer, JH Ko, NC Habibe Burgos, ES Chung… - bioRxiv, 2016 - biorxiv.org
Whole-chromosome aneuploidy is a hallmark of human malignancies. The prevalence of
chromosome segregation errors in cancer – first noted more than 100 years ago – has led to …

A novel biomarker for bacteremia in acute pyelonephritis during pregnancy

C Chatterton, E Jung, D Gallo, R Diaz-Primera… - American Journal of …, 2022 - ajog.org
Objective Sepsis is a leading cause of maternal death and its diagnosis during the golden
hour is critical to improve survival. Acute pyelonephritis, a leading cause of sepsis, is a risk …

[HTML][HTML] Genomic linkages dictate cancer evolution

YBO Snarski, O Shoshani - Cell Reports, 2024 - cell.com
Aneuploidy, a state of chromosome imbalance frequently found in cancer, results in convoluted
cancer genomes. Here, Kuzmin and colleagues 1 identify how the aneuploid genome in …

The Relationship of Knowledge and Attitude for the Prevention of Leucorrhoea in Adolescent Women

FH Wada, FM Rahma, M Shoaliha… - … Malaysian Journal of …, 2023 - ejournal.lucp.net
Introduction: Leucorrhoea is a discharge from the genitalia that is not blood but a clinical
manifestation of various infections, malignancies, or benign tumors of the reproductive organs. …

Engineering large-scale chromosomal deletions by CRISPR-Cas9

TF Eleveld, C Bakali, PP Eijk, P Stathi… - Nucleic acids …, 2021 - academic.oup.com
Large-scale chromosomal deletions are a prevalent and defining feature of cancer. A high
degree of tumor-type and subtype specific recurrencies suggest a selective oncogenic …

Tolerance of chromosomal instability in cancer: mechanisms and therapeutic opportunities

E Gronroos, C López-García - Cancer research, 2018 - AACR
Chromosomal instability (CIN) is the result of ongoing changes in the number (aneuploidy)
and structure of chromosomes. CIN is induced by chromosome missegregation in mitosis and …

Mitotic chromosome alignment ensures mitotic fidelity by promoting interchromosomal compaction during anaphase

CL Fonseca, HLH Malaby, LA Sepaniac… - Journal of Cell …, 2019 - rupress.org
Chromosome alignment at the equator of the mitotic spindle is a highly conserved step
during cell division; however, its importance to genomic stability and cellular fitness is not …

Radiation-induced malignant transformation of preneoplastic and normal breast primary epithelial cells

J Repullés, T Anglada, D Soler, JC Ramírez… - Molecular Cancer …, 2019 - AACR
… BPECs were cultured in WIT-P-NC medium (00-0051, Stemgent; CM-0104, Cellaria)
supplemented with 100 ng/mL cholera toxin (C8052; Sigma-Aldrich) using BD … Habibe Burgos NC

Chromosomal instability and mTORC1 activation through PTEN loss contribute to proteotoxic stress in ovarian carcinoma

MH Chui, SA Doodnauth, N Erdmann, RE Tiedemann… - Cancer Research, 2019 - AACR
Chromosome instability and protein synthesis are important factors that determine the efficacy
of proteotoxic stress-inducing agents, such as proteasome inhibitors, in the treatment of …