Background The dissection of complex traits of economic importance to the pig industry
requires the availability of a significant number of genetic markers, such as single nucleotide …

Germline mutation analysis was performed in 469 VHL families from North America, Europe,
and Japan. Germline mutations were identified in 300/469 (63%) of the families tested; 137 …

Von Hippel-Lindau (VHL) disease is a dominantly inherited familial cancer syndrome
predisposing to a variety of malignant and benign neoplasms, most frequently retinal, cerebellar …

Loss of heterozygosity (LOH) studies have suggested that somatic mutations of a tumour
suppressor gene or genes on chromosome 3p are a critical event In the pathogenesls of non-…

Inactivation of tumour suppressor gene (s)(TSGs) on 3p appears to be a critical event in the
pathogenesis of clear cell renal cell carcinoma (CC-RCC). Analysis of loss of heterozygosity (…

We describe 2 karyotypically male infants with terminal deletion of 10q and mental
retardation, multiple phenotypic anomalies and abnormal genitalia. One [karyotype 46,XY,del(10)(q26…

Von Hippel-Lindau (VHL) disease is a dominantly inherited disorder predisposing to retinal
and CNS hemangioblastomas, renal cell carcinoma (RCC), pheochromocytoma, and …

In mammals, the physiological interaction between spermatozoa and oviductal epithelia
involves intimate and specific contact between the two cell types. Spermatozoa may undergo …

DFFRY (the Y-linked homologue of the DFFRX Drosophila fat-facets related X gene) maps
to proximal Yq11.2 within the interval defining the AZFa spermatogenic phenotype. The …

Intragenomic conflicts arise when a genetic element favours its own transmission to the
detriment of others. Conflicts over sex chromosome transmission are expected to have …