Background Genomewide association studies of autoimmune diseases have mapped hundreds
of susceptibility regions in the genome. However, only for a few association signals has …

The complex network of specialized cells and molecules in the immune system has evolved
to defend against pathogens, but inadvertent immune system attacks on "self" result in …

We report on the influence of ~22 million variants on 731 immune cell traits in a cohort of
3,757 Sardinians. We detected 122 significant (P < 1.28 × 10 −11 ) independent association …

We report ∼17.6 million genetic variants from whole-genome sequencing of 2,120 Sardinians;
22% are absent from previous sequencing-based compilations and are enriched for …

A genome-wide association scan of ∼6.6 million genotyped or imputed variants in 882
Sardinian individuals with multiple sclerosis (cases) and 872 controls suggested association of …

… Skaletsky for detailed information about sequence blocks on the Y chromosome; M. Uda …
Skaletsky for detailed information about sequence blocks on the Y chromosome; M. Uda and R. …

Hepatitis B virus (HBV) has been infecting humans for millennia and remains a global health
problem, but its past diversity and dispersal routes are largely unknown. We generated …

Membranous Nephropathy (MN) is a rare autoimmune cause of kidney failure. Here we
report a genome-wide association study (GWAS) for primary MN in 3,782 cases and 9,038 …

Identifying the genes that influence levels of pro-inflammatory molecules can help to
elucidate the mechanisms underlying this process. We first conducted a two-stage genome-wide …

Deep sequence-based imputation can enhance the discovery power of genome-wide
association studies by assessing previously unexplored variation across the common- and low-…