The reference human genome sequence set the stage for studies of genetic variation and
its association with human disease, but epigenomic studies lack a similar reference. To …

DNA methylation is a defining feature of mammalian cellular identity and is essential for normal
development 1 , 2 . Most cell types, except germ cells and pre-implantation embryos 3 , 4 …

The developmental potential of human pluripotent stem cells suggests that they can produce
disease-relevant cell types for biomedical research. However, substantial variation has …

We investigated the distribution of B and T cells in the peripheral blood of haematologically
inconspicuous (non‐persistent lymphocytotic, PL − ) cattle infected with the bovine …

Although many distinct mutations in a variety of genes are known to cause Amyotrophic Lateral
Sclerosis (ALS), it remains poorly understood how they selectively impact motor neuron …

Brain development is guided by the interactions between the genetic blueprint and the
environment. Epigenetic mechanisms, especially DNA methylation, can mediate these …

DNA methylation is a key epigenetic modification involved in regulating gene expression
and maintaining genomic integrity. Here we inactivated all three catalytically active DNA …

Differentiation of human embryonic stem cells (hESCs) provides a unique opportunity to
study the regulatory mechanisms that facilitate cellular transitions in a human context. To that …

DNA methylation plays an important role in development and disease. The primary sites of
DNA methylation in vertebrates are cytosines in the CpG dinucleotide context, which account …

Background The level of adherence of various pharmacological therapies in chronic diseases
varies, but is predominantly low. With tamoxifen (TAM), 23% and 50% nonadherence after …