Large panels of comprehensively characterized human cancer models, including the Cancer
Cell Line Encyclopedia (CCLE), have provided a rigorous framework with which to study …

Although single-gene perturbation screens have revealed a number of new targets, vulnerabilities
specific to frequently altered drivers have not been uncovered. An important question …

When different types of functional genomics data are generated on single cells from different
samples of cells from the same heterogeneous population, the clustering of cells in the …

Characterizing epigenetic heterogeneity at the cellular level is a critical problem in the modern
genomics era. Assays such as single cell ATAC-seq (scATAC-seq) offer an opportunity to …

Combinatorial CRISPR technologies have emerged as a transformative approach to systematically
probe genetic interactions and dependencies of redundant gene pairs. However, the …

Dimension reduction methods are commonly applied to high-throughput biological datasets.
However, the results can be hindered by confounding factors, either biological or technical …

Abstract Systems for CRISPR-based combinatorial perturbation of two or more genes are
emerging as powerful tools for uncovering genetic interactions. However, systematic …

We are developing a novel intradural spinal cord (SC) stimulator designed to improve the
treatment of intractable pain and the sequelae of SC injury. In-vivo ovine models of …

… Mahdi Zamanighomi is Computational Biologist, Broad Institute of MIT and Harvard,
Cambridge, Massachusetts, USA. Timothy Daley is Postdoctoral Fellow, Department of …

… where |C| indicates the total number of TFs within cluster C and S(C m , TTF) represents the
… Therefore in the maximization step (M-step), we maximize (9) and (10) separately. It can be …