Among the US military personnel, blast injury is among the leading causes of brain injury.
During the past decade, it has become apparent that even blast injury as a form of mild …

Prolonged mechanical ventilation (MV) results in diaphragmatic weakness due to fiber atrophy
and contractile dysfunction. Recent work reveals that activation of the proteases calpain …

In the intestine, finger-like villi provide abundant surface area for nutrient absorption. During
murine villus development, epithelial Hedgehog (Hh) signals promote aggregation of …

… Briefly, muscle was homogenized at 4C using a glass on glass homogenizer in ice-cold cell
lysis buffer (10 mm NaCl, 1.5 mm MgCl 2 , 20 mm Hepes, pH 7.4, 20% glycerol, 0.1% Triton …

Respiratory muscle weakness resulting from both diaphragmatic contractile dysfunction and
atrophy has been hypothesized to contribute to the weaning difficulties associated with …

Objective: To investigate whether apocynin protects the diaphragm from wasting and oxidative
stress during mechanical ventilation (MV). Design: Prospective, randomized, controlled …

… Our data show that M. tuberculosis replicates throughout the course of chronic infection of
mice and is restrained by the host immune system. This approach may also shed light on the …

In 1995, 168 people were killed and 850 others were injured when the Alfred P. Murrah
Building in Oklahoma City was bombed. 2 It was" the worst terrorist attack and the most …

Prevention of oxidative stress via antioxidants attenuates diaphragm myofiber atrophy
associated with mechanical ventilation (MV). However, the specific redox-sensitive mechanisms …

Explosive overpressure brain injury (OBI) impacts the lives of both military and civilian
population. We hypothesize that a single exposure to OBI results in increased hypothalamic …