Embracing the enemy: the diversification of microbial gene repertoires by phage-mediated horizontal gene transfer
… Author links open overlay panel Marie Touchon 1 2 , Jorge A Moura de Sousa 1 2 ,
Eduardo PC Rocha 1 2 … Touchon … Touchon, EPC Rocha …
Eduardo PC Rocha 1 2 … Touchon … Touchon, EPC Rocha …
Genesis, effects and fates of repeats in prokaryotic genomes
DNA repeats are causes and consequences of genome plasticity. Repeats are created by
intrachromosomal recombination or horizontal transfer. They are targeted by recombination …
intrachromosomal recombination or horizontal transfer. They are targeted by recombination …
Selfish, promiscuous and sometimes useful: how mobile genetic elements drive horizontal gene transfer in microbial populations
…, JM de Sousa, M Touchon… - … Transactions of the …, 2022 - royalsocietypublishing.org
Horizontal gene transfer (HGT) drives microbial adaptation but is often under the control of
mobile genetic elements (MGEs) whose interests are not necessarily aligned with those of …
mobile genetic elements (MGEs) whose interests are not necessarily aligned with those of …
[HTML][HTML] Organised Genome Dynamics in the Escherichia coli Species Results in Highly Diverse Adaptive Paths
The Escherichia coli species represents one of the best-studied model organisms, but also
encompasses a variety of commensal and pathogenic strains that diversify by high rates of …
encompasses a variety of commensal and pathogenic strains that diversify by high rates of …
CRISPRCasFinder, an update of CRISRFinder, includes a portable version, enhanced performance and integrates search for Cas proteins
…, C Toffano-Nioche, M Touchon… - Nucleic acids …, 2018 - academic.oup.com
CRISPR (clustered regularly interspaced short palindromic repeats) arrays and their
associated (Cas) proteins confer bacteria and archaea adaptive immunity against exogenous …
associated (Cas) proteins confer bacteria and archaea adaptive immunity against exogenous …
Whole genome-based population biology and epidemiological surveillance of Listeria monocytogenes
…, L Jones, M Touchon, M Tourdjman, M Walker… - Nature …, 2016 - nature.com
Listeria monocytogenes (Lm) is a major human foodborne pathogen. Numerous Lm outbreaks
have been reported worldwide and associated with a high case fatality rate, reinforcing …
have been reported worldwide and associated with a high case fatality rate, reinforcing …
Uncovering Listeria monocytogenes hypervirulence by harnessing its biodiversity
MM Maury, YH Tsai, C Charlier, M Touchon… - Nature …, 2016 - nature.com
Microbial pathogenesis studies are typically performed with reference strains, thereby
overlooking within-species heterogeneity in microbial virulence. Here we integrated human …
overlooking within-species heterogeneity in microbial virulence. Here we integrated human …
[HTML][HTML] Systematic and quantitative view of the antiviral arsenal of prokaryotes
Bacteria and archaea have developed multiple antiviral mechanisms, and genomic evidence
indicates that several of these antiviral systems co-occur in the same strain. Here, we …
indicates that several of these antiviral systems co-occur in the same strain. Here, we …
Pervasive domestication of defective prophages by bacteria
LM Bobay, M Touchon… - Proceedings of the …, 2014 - National Acad Sciences
… S ( A i , B i ) / ( min ( n A , n B ) ) , where S (Ai,Bi) is the similarity score of the pair i of
homologous proteins between (pro)phage A and (pro)phage B (varying from 0.4 to 1), M is the total …
homologous proteins between (pro)phage A and (pro)phage B (varying from 0.4 to 1), M is the total …
[HTML][HTML] Identification of protein secretion systems in bacterial genomes
Bacteria with two cell membranes (diderms) have evolved complex systems for protein
secretion. These systems were extensively studied in some model bacteria, but the …
secretion. These systems were extensively studied in some model bacteria, but the …