Embracing the enemy: the diversification of microbial gene repertoires by phage-mediated horizontal gene transfer

M Touchon, JAM De Sousa, EPC Rocha - Current opinion in microbiology, 2017 - Elsevier
… Author links open overlay panel Marie Touchon 1 2 , Jorge A Moura de Sousa 1 2 ,
Eduardo PC Rocha 1 2 … TouchonTouchon, EPC Rocha …

Genesis, effects and fates of repeats in prokaryotic genomes

TJ Treangen, AL Abraham, M Touchon… - FEMS microbiology …, 2009 - academic.oup.com
DNA repeats are causes and consequences of genome plasticity. Repeats are created by
intrachromosomal recombination or horizontal transfer. They are targeted by recombination …

Selfish, promiscuous and sometimes useful: how mobile genetic elements drive horizontal gene transfer in microbial populations

…, JM de Sousa, M Touchon… - … Transactions of the …, 2022 - royalsocietypublishing.org
Horizontal gene transfer (HGT) drives microbial adaptation but is often under the control of
mobile genetic elements (MGEs) whose interests are not necessarily aligned with those of …

[HTML][HTML] Organised Genome Dynamics in the Escherichia coli Species Results in Highly Diverse Adaptive Paths

M Touchon, C Hoede, O Tenaillon, V Barbe… - PLoS …, 2009 - journals.plos.org
The Escherichia coli species represents one of the best-studied model organisms, but also
encompasses a variety of commensal and pathogenic strains that diversify by high rates of …

CRISPRCasFinder, an update of CRISRFinder, includes a portable version, enhanced performance and integrates search for Cas proteins

…, C Toffano-Nioche, M Touchon… - Nucleic acids …, 2018 - academic.oup.com
CRISPR (clustered regularly interspaced short palindromic repeats) arrays and their
associated (Cas) proteins confer bacteria and archaea adaptive immunity against exogenous …

Whole genome-based population biology and epidemiological surveillance of Listeria monocytogenes

…, L Jones, M Touchon, M Tourdjman, M Walker… - Nature …, 2016 - nature.com
Listeria monocytogenes (Lm) is a major human foodborne pathogen. Numerous Lm outbreaks
have been reported worldwide and associated with a high case fatality rate, reinforcing …

Uncovering Listeria monocytogenes hypervirulence by harnessing its biodiversity

MM Maury, YH Tsai, C Charlier, M Touchon… - Nature …, 2016 - nature.com
Microbial pathogenesis studies are typically performed with reference strains, thereby
overlooking within-species heterogeneity in microbial virulence. Here we integrated human …

[HTML][HTML] Systematic and quantitative view of the antiviral arsenal of prokaryotes

F Tesson, A Hervé, E Mordret, M Touchon… - Nature …, 2022 - nature.com
Bacteria and archaea have developed multiple antiviral mechanisms, and genomic evidence
indicates that several of these antiviral systems co-occur in the same strain. Here, we …

Pervasive domestication of defective prophages by bacteria

LM Bobay, M Touchon… - Proceedings of the …, 2014 - National Acad Sciences
… S ( A i , B i ) / ( min ( n A , n B ) ) , where S (Ai,Bi) is the similarity score of the pair i of
homologous proteins between (pro)phage A and (pro)phage B (varying from 0.4 to 1), M is the total …

[HTML][HTML] Identification of protein secretion systems in bacterial genomes

SS Abby, J Cury, J Guglielmini, B Néron, M Touchon… - Scientific reports, 2016 - nature.com
Bacteria with two cell membranes (diderms) have evolved complex systems for protein
secretion. These systems were extensively studied in some model bacteria, but the …