Germline CDH1 mutations confer a high lifetime risk of developing diffuse gastric (DGC) and
lobular breast cancer (LBC). A multidisciplinary workshop was organised to discuss genetic …

Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer syndrome that is
characterised by a high prevalence of diffuse gastric cancer and lobular breast cancer. It is …

The European Collaborative on Personalized Early Detection and Prevention of Breast Cancer
(ENVISION) brings together several international research consortia working on different …

Importance The clinical management ofBRCA1andBRCA2mutation carriers requires accurate,
prospective cancer risk estimates. Objectives To estimate age-specific risks of breast, …

Background Olaparib (AZD2281) is a small-molecule, potent oral poly(ADP-ribose) polymerase
(PARP) inhibitor. We aimed to assess the safety and tolerability of this drug in patients …

Background Germline loss-of-function mutations in PALB2 are known to confer a predisposition
to breast cancer. However, the lifetime risk of breast cancer that is conferred by such …

Background Reliable estimates of cancer risk are critical for guiding management of BRCA1
and BRCA2 mutation carriers. The aims of this study were to derive penetrance estimates …

An international group of cancer geneticists review the level of evidence for the association
of gene variants with the risk of breast cancer. It is difficult to draw firm conclusions from the …

… When considering only nonmetastatic patients (M 0 ) at diagnosis, 5-year CSS_M 0 in
noncarriers was significantly improved compared with carriers (96% v 82%; P = 9 × 10 −8 ), but …

PALB2 was recently identified as a nuclear binding partner of BRCA2. Biallelic BRCA2
mutations cause Fanconi anemia subtype FA-D1 and predispose to childhood malignancies. We …