Background A widespread modulation of gene expression occurs in the aging brain, but
little is known as to the upstream drivers of these changes. MicroRNAs emerged as fine …

Many RNA-binding proteins (RBPs), particularly those associated with RNA granules, promote
pathological protein aggregation in neurodegenerative diseases. Here, we demonstrate …

Tau is a microtubule-associated protein (MAPT, tau) implicated in the pathogenesis of
tauopathies, a spectrum of neurodegenerative disorders characterized by accumulation of …

Brain injuries causing chronic sensory or motor deficit, such as stroke, are among the leading
causes of disability worldwide, according to the World Health Organization; furthermore, …

Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by the loss of
neuronal E3 ligase UBE3A. Restoring UBE3A levels is a potential disease-modifying therapy …

Economic efficiency has been a popular explanation for how networks self-organize within
the developing nervous system. However, the precise nature of the economic negotiations …

… (I, J, L, and M) WiBi and CHIR8 fiber density in cortical (I and L) and extra-cortical (J and M)
regions, 1 (I and J) and 2 months (L and M) after transplantation; Error bars, SD. *p < 0.05; **…

Cerebral cortical development is controlled by key transcription factors that specify the neuronal
identities in the different layers. The mechanisms controlling their expression in distinct …

Antibody libraries are important resources to derive antibodies to be used for a wide range
of applications, from structural and functional studies to intracellular protein interference …

Studies have provided evidence that human cerebral organoids (hCOs) recapitulate fundamental
milestones of early brain development, but many important questions regarding their …