Digital pathology and image analysis in tissue biomarker research

…, D Kieran, DG McArt, J James, M Salto-Tellez - Methods, 2014 - Elsevier
Digital pathology and the adoption of image analysis have grown rapidly in the last few years.
This is largely due to the implementation of whole slide scanning, advances in software …

Targeting c-MET in gastrointestinal tumours: rationale, opportunities and challenges

CA Bradley, M Salto-Tellez, P Laurent-Puig… - Nature reviews Clinical …, 2017 - nature.com
Data from many preclinical studies, including those using cellular models of colorectal,
gastric, gastro-oesophageal and gastro-oesophageal junction cancers, indicate that the …

Potential roles for the PIM1 kinase in human cancer–a molecular and therapeutic appraisal

…, S Thorn, CS Chen, MB Lilly, M Salto-Tellez - European journal of …, 2008 - Elsevier
… Financial support: M. Salto-Tellez receives funding support from SCS Grants MN-005 and
MN-077, awarded by the Singapore Cancer Syndicate, Agency for Science, Technology and …

[HTML][HTML] QuPath: Open source software for digital pathology image analysis

…, LJ Murray, HG Coleman, JA James, M Salto-Tellez… - Scientific reports, 2017 - nature.com
QuPath is new bioimage analysis software designed to meet the growing need for a user-friendly,
extensible, open-source solution for digital pathology and whole slide image analysis. …

[HTML][HTML] Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury

…, MM Lee, NSK Sze, A Choo, TS Chen, M Salto-Tellez… - Stem cell …, 2010 - Elsevier
Human ESC-derived mesenchymal stem cell (MSC)-conditioned medium (CM) was previously
shown to mediate cardioprotection during myocardial ischemia/reperfusion injury through …

Hydrogen sulfide is a novel mediator of lipopolysaccharide‐induced inflammation in the mouse

…, FBM Anuar, M Whiteman, M SaltoTellez… - The FASEB …, 2005 - Wiley Online Library
… Subsequently, N,N-dimethyl-p-phenylenediamine sulfate (20 µM; 133 µl) in 7.2 M HCl was
added followed by FeCl3 (30 µM; 133 µl) in 1.2 M HCl, and absorbance (670 nm) of aliquots …

Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes

…, J Wu, D Poh, WK Wan, SY Rha, J So, M Salto-Tellez… - Nature …, 2012 - nature.com
Gastric cancer is a major cause of global cancer mortality. We surveyed the spectrum of
somatic alterations in gastric cancer by sequencing the exomes of 15 gastric adenocarcinomas …

[HTML][HTML] Inhibition of histone deacetylase 2 increases apoptosis and p21Cip1/WAF1 expression, independent of histone deacetylase 1

…, CHW Leung, L Lee, CK Lee, M Salto-Tellez… - Cell Death & …, 2005 - nature.com
Histone deacetylases (HDACs) 1 and 2 share a high degree of homology and coexist within
the same protein complexes. Despite their close association, each possesses unique …

Activation of STING-dependent innate immune signaling by S-phase-specific DNA damage in breast cancer

…, NE Buckley, KI Savage, M Salto-Tellez… - Journal of the …, 2017 - academic.oup.com
Background: Previously we identified a DNA damage response–deficient (DDRD) molecular
subtype within breast cancer. A 44-gene assay identifying this subtype was validated as …

Intrinsic subtypes of gastric cancer, based on gene expression pattern, predict survival and respond differently to chemotherapy

…, SH Noh, WK Wan, JA Ajani, JS Lee, M SaltoTellez… - Gastroenterology, 2011 - Elsevier
BACKGROUND & AIMS: Gastric cancer (GC) is a heterogeneous disease comprising
multiple subtypes that have distinct biological properties and effects in patients. We sought to …