plasmidSPAdes: assembling plasmids from whole genome sequencing data
Motivation: Plasmids are stably maintained extra-chromosomal genetic elements that replicate
independently from the host cell’s chromosomes. Although plasmids harbor biomedically …
independently from the host cell’s chromosomes. Although plasmids harbor biomedically …
Metaviral SPAdes: assembly of viruses from metagenomic data
Motivation Although the set of currently known viruses has been steadily expanding, only a
tiny fraction of the Earth’s virome has been sequenced so far. Shotgun metagenomic …
tiny fraction of the Earth’s virome has been sequenced so far. Shotgun metagenomic …
Plasmid detection and assembly in genomic and metagenomic data sets
Although plasmids are important for bacterial survival and adaptation, plasmid detection and
assembly from genomic, let alone metagenomic, samples remain challenging. The recently …
assembly from genomic, let alone metagenomic, samples remain challenging. The recently …
[HTML][HTML] Ovarian cancer population screening and mortality after long-term follow-up in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a …
Background Ovarian cancer continues to have a poor prognosis with the majority of women
diagnosed with advanced disease. Therefore, we undertook the UK Collaborative Trial of …
diagnosed with advanced disease. Therefore, we undertook the UK Collaborative Trial of …
Cost effectiveness of an intensive blood glucose control policy in patients with type 2 diabetes: economic analysis alongside randomised controlled trial (UKPDS 41)
Objective: To estimate the cost effectiveness of conventional versus intensive blood glucose
control in patients with type 2 diabetes. Design: Incremental cost effectiveness analysis …
control in patients with type 2 diabetes. Design: Incremental cost effectiveness analysis …
Cost-effectiveness of population screening for BRCA mutations in Ashkenazi Jewish women compared with family history–based testing
Background: Population-based testing for BRCA1/2 mutations detects the high proportion of
carriers not identified by cancer family history (FH)–based testing. We compared the cost-…
carriers not identified by cancer family history (FH)–based testing. We compared the cost-…
The economics of screening and treatment in type 2 diabetes mellitus
A systematic review of the literature was conducted to identify articles on the economics of
type 2 diabetes mellitus. Articles were classified into two main categories: cost/burden-of-…
type 2 diabetes mellitus. Articles were classified into two main categories: cost/burden-of-…
Cost-effectiveness analysis of intensive blood-glucose control with metformin in overweight patients with type II diabetes (UKPDS No. 51)
Aims/hypothesis. To estimate the economic efficiency of intensive blood-glucose control with
metformin compared with conventional therapy primarily with diet in overweight patients …
metformin compared with conventional therapy primarily with diet in overweight patients …
Cluster-randomised non-inferiority trial comparing DVD-assisted and traditional genetic counselling in systematic population testing for BRCA1/2 mutations
Background Newer approaches to genetic counselling are required for population-based
testing. We compare traditional face-to-face genetic counselling with a DVD-assisted approach …
testing. We compare traditional face-to-face genetic counselling with a DVD-assisted approach …
Cost‐effectiveness analysis of oxaliplatin compared with 5‐fluorouracil/leucovorin in adjuvant treatment of stage III colon cancer in the US
… /m 2 on Day 1, leucovorin 200 mg/m 2 on Days 1 and 2, 5-FU bolus 400 mg/m 2 and 5-FU
continuous infusion 600 mg/m 2 … 200 mg/m 2 and Days 1 and 2, 5-FU bolus 400 mg/m 2 and 5-…
continuous infusion 600 mg/m 2 … 200 mg/m 2 and Days 1 and 2, 5-FU bolus 400 mg/m 2 and 5-…