About half of all cancers have somatic integrations of retrotransposons. Here, to characterize
their role in oncogenesis, we analyzed the patterns and mechanisms of somatic …

Mantle cell lymphoma (MCL) is a mature B-cell neoplasm initially driven by CCND1 rearrangement
with 2 molecular subtypes, conventional MCL (cMCL) and leukemic non-nodal MCL (…

Extrachromosomal circularization of DNA is an important genomic feature in cancer. However,
the structure, composition and genome-wide frequency of extrachromosomal circular …

MYCN amplification drives one in six cases of neuroblastoma. The supernumerary gene
copies are commonly found on highly rearranged, extrachromosomal circular DNA (ecDNA). …

Chronic lymphocytic leukemia (CLL) is a frequent hematological neoplasm in which
underlying epigenetic alterations are only partially understood. Here, we analyze the reference …

The impact of large and complex epigenomic datasets on biological insights or clinical
applications is limited by the lack of accessibility by easy, intuitive, and fast tools. Here, we …

The reanalysis of existing GWAS data represents a powerful and cost-effective opportunity
to gain insights into the genetics of complex diseases. By reanalyzing publicly available type …

The development of high-throughput sequencing technologies has advanced our understanding
of cancer. However, characterizing somatic structural variants in tumor genomes is still …

Genome-wide association studies (GWASs) identified hundreds of signals associated with
type 2 diabetes (T2D). To gain insight into their underlying molecular mechanisms, we have …

… Using this strategy we imputed 2.6 M and 5.5 M high-… M indels. Note that as many as 684,393
common variants (MAF ≥ 0.05), 255,106 low-frequency, 1.7 M rare, and all indels (1.6 M) …