Marine stickleback fish have colonized and adapted to thousands of streams and lakes
formed since the last ice age, providing an exceptional opportunity to characterize genomic …

Cancer drugs often induce dramatic responses in a small minority of patients. We used
whole-genome sequencing to investigate the genetic basis of a durable remission of metastatic …

Common acquired melanocytic nevi are benign neoplasms that are composed of small,
uniform melanocytes and are typically present as flat or slightly elevated pigmented lesions on …

A large number of computational methods have been developed for analyzing differential
gene expression in RNA-seq data. We describe a comprehensive evaluation of common …

… Pirun JPM MGF JJ EM JA FdP ESL. Performed the experiments: JRSM A. Lundquist …
Analyzed the data: MPH MGG JRSM NZ GS BTM JTM EM M. Pirun AZ. Contributed reagents/…

Genetically engineered mouse models (GEMMs) of cancer are increasingly being used to
assess putative driver mutations identified by large-scale sequencing of human cancer …

… In human tumors with admixed non-neoplastic cells, heterozygous mutant (M) peaks are
typically smaller than the wild-type (WT) allele peaks. The cases with LOH at MYOD1 by …

Metastatic solid tumors are almost invariably fatal. Patients with disseminated small-cell cancers
have a particularly unfavorable prognosis, with most succumbing to their disease within …

Angiosarcomas are rare malignant mesenchymal tumors of endothelial differentiation. The
clinical behavior is usually aggressive and the prognosis for patients with advanced disease …

… The scaffolds were then ashed overnight at 850C and solubilized in 5 mL of 1 M HCl.
Residual calcium content was then determined by the o-cresolphthalein complexone calcium-…