User profiles for M. Petrascheck
Michael PetrascheckThe Scripps Research Institute Verified email at scripps.edu Cited by 2949 |
The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR
Metabolism and ageing are intimately linked. Compared with ad libitum feeding, dietary
restriction consistently extends lifespan and delays age-related diseases in evolutionarily …
restriction consistently extends lifespan and delays age-related diseases in evolutionarily …
An antidepressant that extends lifespan in adult Caenorhabditis elegans
M Petrascheck, X Ye, LB Buck - Nature, 2007 - nature.com
The mechanisms that determine the lifespan of an organism are still largely a mystery 1 .
One goal of ageing research is to find drugs that would increase lifespan and vitality when …
One goal of ageing research is to find drugs that would increase lifespan and vitality when …
[PDF][PDF] C. elegans as model for drug discovery
M Carretero, GM Solis, M Petrascheck - Curr Top Med Chem, 2017 - researchgate.net
Small molecule screens using C. elegans as a model are becoming increasingly popular as
the number of high-throughput methodologies has steadily increased over the years. Here …
the number of high-throughput methodologies has steadily increased over the years. Here …
Measuring Caenorhabditis elegans life span in 96 well microtiter plates
GM Solis, M Petrascheck - JoVE (Journal of Visualized Experiments), 2011 - jove.com
Lifespan is a biological process regulated by several genetic pathways. One strategy to
investigate the biology of aging is to study animals that harbor mutations in components of age-…
investigate the biology of aging is to study animals that harbor mutations in components of age-…
The DrugAge database of aging‐related drugs
…, A Budovsky, N Araujo, J Gruber, M Petrascheck… - Aging cell, 2017 - Wiley Online Library
Aging is a major worldwide medical challenge. Not surprisingly, identifying drugs and compounds
that extend lifespan in model organisms is a growing research area. Here, we present …
that extend lifespan in model organisms is a growing research area. Here, we present …
Geroneuroprotectors: effective geroprotectors for the brain
…, A Currais, J Goldberg, K Finley, M Petrascheck… - Trends in …, 2018 - cell.com
Geroprotectors are compounds that slow the rate of biological aging and therefore may
reduce the incidence of age-associated diseases such as Alzheimer's disease (AD). However, …
reduce the incidence of age-associated diseases such as Alzheimer's disease (AD). However, …
The mitochondrial ATP synthase is a shared drug target for aging and dementia
…, JM Cuezva, P Maher, M Petrascheck… - Aging cell, 2018 - Wiley Online Library
… We tested J147's effect on Δψ m using JC1, a ratiometric cationic dye. A … Δψ m , we
performed siRNA-targeted knockdown of ATP5A (Figure 2d) and found a similar increase in Δψ m …
performed siRNA-targeted knockdown of ATP5A (Figure 2d) and found a similar increase in Δψ m …
A pharmacological network for lifespan extension in Caenorhabditis elegans
…, JM Linton, NJ Schork, LB Buck, M Petrascheck - Aging cell, 2014 - Wiley Online Library
One goal of aging research is to find drugs that delay the onset of age‐associated disease.
Studies in invertebrates, particularly C aenorhabditis elegans, have uncovered numerous …
Studies in invertebrates, particularly C aenorhabditis elegans, have uncovered numerous …
The aging transcriptome: read between the lines
…, JN Buxbaum, M Petrascheck - Current opinion in …, 2020 - Elsevier
… Author links open overlay panel Anabel Perez-Gomez 1 2 , Joel N Buxbaum 1 3 ,
Michael Petrascheck 1 2 … Petrascheck … Petrascheck, AB Niculescu …
Michael Petrascheck 1 2 … Petrascheck … Petrascheck, AB Niculescu …
Proton pump inhibitors accelerate endothelial senescence
…, TZ Nazari-Shafti, M Petrascheck… - Circulation …, 2016 - Am Heart Assoc
Rationale: Proton pump inhibitors (PPIs) are popular drugs for gastroesophageal reflux, which
are now available for long-term use without medical supervision. Recent reports suggest …
are now available for long-term use without medical supervision. Recent reports suggest …