… To a -20 C solutionof 4 (0.5 mmol, 290 mg) in dry pyridine (3 mL) was added dropwise a
1 M solution of hydrazine in tetrahydrofuran (0.5 mmol, 500 gL). After 0.5 h ferf-butyldiphenylsilyl …

To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide
association studies in 87,802 women of European descent, with replication in up to 14,731 …

Background Genomewide association studies of autoimmune diseases have mapped hundreds
of susceptibility regions in the genome. However, only for a few association signals has …

Clonal expansions driven by somatic mutations become pervasive across human tissues
with age, including in the haematopoietic system, where the phenomenon is termed clonal …

To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22
genome-wide association studies (GWAS) in 38,968 women of European descent, with …

The complex network of specialized cells and molecules in the immune system has evolved
to defend against pathogens, but inadvertent immune system attacks on "self" result in …

We report on the influence of ~22 million variants on 731 immune cell traits in a cohort of
3,757 Sardinians. We detected 122 significant (P < 1.28 × 10 −11 ) independent association …

Progressive iron overload is the most salient and ultimately fatal complication of β-thalassemia.
However, little is known about the relationship among ineffective erythropoiesis (IE), the …

Long-duration γ-ray bursts (GRBs) originate from ultra-relativistic jets launched from the
collapsing cores of dying massive stars. They are characterized by an initial phase of bright and …

Excessive iron absorption is one of the main features of β-thalassemia and can lead to
severe morbidity and mortality. Serial analyses of β-thalassemic mice indicate that while …