HLA class I downregulation is a frequent event associated with tumour invasion and
development. Altered HLA class I tumour phenotypes can have profound effects on T-cell and …

Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers
and proportions of peripheral immune cells in infected-vs-uninfected people. Because the …

… Author links open overlay panel Aura Muntasell 1 , Maria C Ochoa 2 , Luna Cordeiro 2 ,
Pedro Berraondo 1 , Ascension López-Díaz de Cerio 3 , Mariona Cabo 1 , Miguel López-Botet 1 …

The lytic function of human natural killer (NK) cells is markedly influenced by recognition of
class I major histocompatibility complex (MHC) molecules, a process mediated by several …

… Bellon and M. Lopez -Botet, unpublished). The existence of a minor population of CD94/NKG2C+
NKG2A– decidual lymphocytes is not ruled out. Yet, CD94/NKG2C-specific mAb are …

… M. HLA-E expression was assessed by flow cytometry; peptide-loaded cells were washed
… Acknowledgements: We thank M. Carretero for helpful discussion. The expert assistance of …

We previously showed that the availability of a nonamer peptide derived from certain HLA
class I signal sequences is a necessary requirement for the stabilization of endogenous HLA-…

Natural killer (NK) cell–mediated lysis is negatively regulated by killer cell inhibitory receptors
specific for major histocompatibility complex (MHC) class I molecules. In this study, we …

… López-Botet M, Angulo A, Gumá M. Natural killer cell receptors for major histocompatibility
complex … de Miguel M, López-Botet M. Characterization of monoclonal antibodies specific for …

In this report, we describe a novel activation antigen that appears very early after T cell
activation and is absent in resting lymphocytes, through which agonistic proliferative signals can …