The potential of the diverse chemistries present in natural products (NP) for biotechnology
and medicine remains untapped because NP databases are not searchable with raw data …

Covering: 2013 to 2019 The exploration of the chemical diversity of extracts from various
biological sources has led to major drug discoveries. Over the past two decades, despite the …

… Tandem MS/MS offers structural insights by breaking the analyzed ion into fragment ions
and measuring their m/z ratio. Tandem MS/MS data is thus more discriminant in a dereplication …

… The precursor ion mass tolerance was set to 0.01 Da and to a product ion tolerance of 0.0075
Da (allowing a maximum error of 25 ppm at m/z 300 and 12 ppm at m/z 600). The fragment …

Variolin B (1), a new type of pyridopyrrolopyrimidine alkaloid with antitumour and antiviral
properties, has been isolated from the Antarctic sponge Kirkpatrickia varialosa, and its …

ETHNOPHARMACOLOGICAL RELEVANCE: Baicalein, the active constituent derived from
Scutellaria baicalensis Georgi., has previously been shown to significantly restore the …

… , followed by its associated MS 2 scan data (m/z, intensity pairs). The precursor ion mass
entry was filled with the data from the average m/z column, the retention time information was …

… lineata data set, a peak alignment step was performed using the join aligner module [m/z
tolerance of 0.004 (or 10 ppm), weight for m/z of 1, weight for RT of 1, and absolute RT …

… Mass spectra were recorded from m/z 50 to m/z 1000 at 2 GHz, leading to a mass resolution
of 20 000 at m/z 922. A MS 1 scan was followed by MS/MS scans of the three most intense …

Alkaloid extracts of leaves (OOL) and bark (OOB) of Ochrosia oppositifolia, as well as
isoreserpiline (ISR), the major alkaloid isolated from OOL and OOB, were investigated as potential …