Cohesins mediate sister chromatid cohesion, which is essential for chromosome segregation
and postreplicative DNA repair. In addition, cohesins appear to regulate gene expression …

Regulatory T (Treg) cells safeguard against autoimmunity and immune pathology. Because
determinants of the Treg cell fate are not completely understood, we have delineated …

Parkinson’s disease (PD) is characterized by the accumulation of misfolded and aggregated
α-synuclein (α-syn) into intraneuronal inclusions named Lewy bodies (LBs). Although it is …

The spatial and temporal control of Hox gene transcription is essential for patterning the
vertebrate body axis. Although this process involves changes in histone posttranslational …

Introduction During vertebrate limb development, gene members of the HoxD cluster are
transcribed in two subsequent waves, following a collinear strategy. Early on, genes located in …

Polycomb Repressor Complexes (PRCs) are important regulators of embryogenesis. In
embryonic stem (ES) cells many genes that regulate subsequent stages in development are …

Efforts to precisely identify tumor human leukocyte antigen (HLA) bound peptides capable
of mediating T cell-based tumor rejection still face important challenges. Recent studies …

Chromatin immunoprecipitation followed by deep sequencing (ChIP-seq) experiments are
widely used to determine, within entire genomes, the occupancy sites of any protein of interest…

During development, expression of the Hoxa and Hoxd genes in zebrafish fins and mouse
limbs are regulated via a conserved chromatin structure. However, zebrafish lack certain …

Embryogenesis requires the precise activation and repression of many transcriptional
regulators. The Polycomb group proteins and the associated H3K27me3 histone mark are …