In many species, introduction of double-stranded RNA (dsRNA) induces potent and specific
gene silencing, a phenomenon called RNA interference or RNAi. The apparently …

The ‘sterol-sensing domain' (SSD) is conserved across phyla and is present in several
membrane proteins, such as Patched (a Hedgehog receptor) and NPC-1 (the protein defective in …

Epithelial cells play a central role in many embryonic morphogenetic processes, during
which they undergo highly coordinated cell shape changes. Here, we review some common …

We describe a set of replicative, integrative and single‐stranded shuttle vectors constructed
from the pUC19 plasmid that we use routinely in our experiments. They bear a yeast …

Polarized intracellular trafficking in epithelia is critical in development, immunity, and physiology
to deliver morphogens, defensins, or ion pumps to the appropriate membrane domain. …

… Here, Michel Labouesse and colleagues describe a mechanotransduction pathway that
links the body wall with the epidermis in the roundworm Caenorhabditis elegans. The pathway …

To build complex organs, embryos have evolved mechanisms that integrate the development
of cells unrelated to one another by cell type or ancestry. Here we show that the pha-4 …

… Goetz, Michel Labouesse; RAL-1 controls multivesicular body biogenesis and exosome
secretion. J Cell Biol 12 October 2015; 211 (1): 27–37. doi: https://doi.org/10.1083/jcb.…

Prenatal exposure to infectious or inflammatory insults is increasingly recognized to contribute
to the etiology of psychiatric disorders with neurodevelopmental components, including …

Morphogenesis of the Caenorhabditis elegans embryo is driven by actin microfilaments in the
epidermis and by sarcomeres in body wall muscles. Both tissues are mechanically coupled…