User profiles for M. Kaakinen

Marika A Kaakinen

Visiting researcher, Imperial College London
Verified email at imperial.ac.uk
Cited by 29673

Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption

…, I Barroso, I Johansson, L Xue, M Kaakinen… - Molecular …, 2015 - nature.com
Coffee, a major dietary source of caffeine, is among the most widely consumed beverages in
the world and has received considerable attention regarding health risks and benefits. We …

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

…, M Kaakinen, J Kaprio, YA Kesaniemi, M Kivimaki… - Nature …, 2010 - nature.com
Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic
traits, we performed meta-analyses of 21 genome-wide association studies informative for …

[HTML][HTML] Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts

…, MI McCarthy, J Dupuis, M Kaakinen… - PLoS …, 2013 - journals.plos.org
Background Obesity is associated with vitamin D deficiency, and both are areas of active
public health concern. We explored the causality and direction of the relationship between …

Genome-wide association study identifies 74 loci associated with educational attainment

…, PK Joshi, A Jugessur, MA Kaakinen, M Kähönen… - Nature, 2016 - nature.com
Educational attainment is strongly influenced by social and other environmental factors, but
genetic factors are estimated to account for at least 20% of the variation across individuals 1. …

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

…, JJ Hottenga, Å Johansson, T Johnson, M Kaakinen… - Nature …, 2010 - nature.com
Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic
consequences independent of overall adiposity. WHR is heritable, but few genetic variants …

Common variants associated with plasma triglycerides and risk for coronary artery disease

…, AU Jackson, Å Johansson, T Johnson, M Kaakinen… - Nature …, 2013 - nature.com
Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in
epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery …

GWAS of 126,559 individuals identifies genetic variants associated with educational attainment

…, B Jacobsson, PK Joshi, A Jugessur, M Kaakinen… - science, 2013 - science.org
A genome-wide association study (GWAS) of educational attainment was conducted in a
discovery sample of 101,069 individuals and a replication sample of 25,490. Three …

Variants in MTNR1B influence fasting glucose levels

…, S Sanna, JJ Hottenga, E Wheeler, M Kaakinen… - Nature …, 2009 - nature.com
To identify previously unknown genetic loci associated with fasting glucose concentrations,
we examined the leading association signals in ten genome-wide association scans …

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

…, JJ Hottenga, PL De Jager, MA Kaakinen… - Nature …, 2016 - nature.com
Very few genetic variants have been associated with depression and neuroticism, likely
because of limitations on sample size in previous studies. Subjective well-being, a phenotype …

Genome-wide association analysis of metabolic traits in a birth cohort from a founder population

…, CG Jones, NA Zaitlen, T Varilo, M Kaakinen… - Nature …, 2009 - nature.com
Genome-wide association studies (GWAS) of longitudinal birth cohorts enable joint investigation
of environmental and genetic influences on complex traits. We report GWAS results for …