Plasmodium vivax is a major cause of febrile illness in endemic areas of Asia, Central and
South America, and the horn of Africa. P. vivax infections are characterized by relapses of …

Background Artemisinin-based combination therapies are the recommended first-line treatments
of falciparum malaria in all countries with endemic disease. There are recent concerns …

Background Artemisinin resistance in Plasmodium falciparum has emerged in Southeast Asia
and now poses a threat to the control and elimination of malaria. Mapping the geographic …

Little is known of the genetic diversity and population structure of Plasmodium vivax, a
debilitating and highly prevalent malaria parasite of humans. This article reviews the known …

Background Evidence suggests that the PfKelch13 mutations that confer artemisinin
resistance in falciparum malaria have multiple independent origins across the Greater Mekong …

We report a large multicenter genome-wide association study of Plasmodium falciparum
resistance to artemisinin, the frontline antimalarial drug. Across 15 locations in Southeast Asia, …

We describe an analysis of genome variation in 825 P. falciparum samples from Asia and
Africa that identifies an unusual pattern of parasite population structure at the epicenter of …

Malaria elimination strategies require surveillance of the parasite population for genetic
changes that demand a public health response, such as new forms of drug resistance 1 , 2 . …

Background . Malaria in humans is caused by apicomplexan parasites belonging to 5 species
of the genus Plasmodium. Infections with Plasmodium ovale are widely distributed but …

Background Emergence of artemisinin resistance in southeast Asia poses a serious threat
to the global control of Plasmodium falciparum malaria. Discovery of the K13 marker has …