User profiles for M. Heltberg
Mathias HeltbergPostdoc, Niels Bohr Institute Verified email at nbi.ku.dk Cited by 411 |
Single molecule microscopy reveals key physical features of repair foci in living cells
J Miné-Hattab, M Heltberg, M Villemeur, C Guedj… - Elife, 2021 - elifesciences.org
In response to double strand breaks (DSB), repair proteins accumulate at damaged sites,
forming membrane-less sub-compartments or foci. Here we explored the physical nature of …
forming membrane-less sub-compartments or foci. Here we explored the physical nature of …
[HTML][HTML] On chaotic dynamics in transcription factors and the associated effects in differential gene regulation
… All scripts to generate the data are available upon request at heltberg@nbi.ku.dk or
mhjensen@nbi.dk. The majority of scripts can also be found at https://github.com/Mathiasheltberg/…
mhjensen@nbi.dk. The majority of scripts can also be found at https://github.com/Mathiasheltberg/…
[PDF][PDF] Enhanced DNA repair through droplet formation and p53 oscillations
MS Heltberg, A Lucchetti, FS Hsieh, DPM Nguyen… - Cell, 2022 - cell.com
Living organisms are constantly exposed to DNA damage, and optimal repair is therefore
crucial. A characteristic hallmark of the response is the formation of sub-compartments around …
crucial. A characteristic hallmark of the response is the formation of sub-compartments around …
[HTML][HTML] Noise induces hopping between NF-κB entrainment modes
Oscillations and noise drive many processes in biology, but how both affect the activity of the
transcription factor nuclear factor κB (NF-κB) is not understood. Here, we observe that when …
transcription factor nuclear factor κB (NF-κB) is not understood. Here, we observe that when …
[PDF][PDF] A tale of two rhythms: Locked clocks and chaos in biology
… chaos from lower dimensional dynamics, is to construct a Poincare section inside the embedded
attractor and determine the correlations of the points in this section (Heltberg et al., 2017…
attractor and determine the correlations of the points in this section (Heltberg et al., 2017…
[PDF][PDF] Chaotic dynamics mediate brain state transitions, driven by changes in extracellular ion concentrations
Previous studies have suggested that changes in extracellular ion concentrations initiate
the transition from an activity state that characterizes sleep in cortical neurons to states that …
the transition from an activity state that characterizes sleep in cortical neurons to states that …
Coupled oscillator cooperativity as a control mechanism in chronobiology
MS Heltberg, Y Jiang, Y Fan, Z Zhang, MS Nordentoft… - Cell Systems, 2023 - cell.com
Control of dynamical processes is vital for maintaining correct cell regulation and cell-fate
decisions. Numerous regulatory networks show oscillatory behavior; however, our knowledge …
decisions. Numerous regulatory networks show oscillatory behavior; however, our knowledge …
Physical observables to determine the nature of membrane-less cellular sub-compartments
The spatial organization of complex biochemical reactions is essential for the regulation of
cellular processes. Membrane-less structures called foci containing high concentrations of …
cellular processes. Membrane-less structures called foci containing high concentrations of …
[HTML][HTML] A possible universal role for mRNA secondary structure in bacterial translation revealed using a synthetic operon
In bacteria, translation re-initiation is crucial for synthesizing proteins encoded by genes that
are organized into operons. The mechanisms regulating translation re-initiation remain, …
are organized into operons. The mechanisms regulating translation re-initiation remain, …
[HTML][HTML] Machine-learning vs. logistic regression for preoperative prediction of medical morbidity after fast-track hip and knee arthroplasty—a comparative study
C Michelsen, CC Jørgensen, M Heltberg… - BMC …, 2023 - Springer
Background Machine-learning models may improve prediction of length of stay (LOS) and
morbidity after surgery. However, few studies include fast-track programs, and most rely on …
morbidity after surgery. However, few studies include fast-track programs, and most rely on …