In this era of complete genomes, our knowledge of neuroanatomical circuitry remains
surprisingly sparse. Such knowledge is critical, however, for both basic and clinical research into …

To understand the function of cortical circuits, it is necessary to catalog their cellular diversity.
Past attempts to do so using anatomical, physiological or molecular features of cortical …

The Allen Mouse Brain Connectivity Atlas is a mesoscale whole brain axonal projection atlas
of the C57Bl/6J mouse brain. Anatomical trajectories throughout the brain were mapped …

Molecular approaches to understanding the functional circuitry of the nervous system
promise new insights into the relationship between genes, brain and behaviour. The cellular …

The Cre/lox system is widely used in mice to achieve cell-type-specific gene expression.
However, a strong and universally responding system to express genes under Cre control is still …

Neuroanatomically precise, genome-wide maps of transcript distributions are critical resources
to complement genomic sequence data and to correlate functional and genetic brain …

Comprehensive knowledge of the brain’s wiring diagram is fundamental for understanding
how the nervous system processes information at both local and global scales. However, with …

The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally
conserved across mammals 1 . Here, using high-throughput transcriptomic and epigenomic …

The neocortex contains a multitude of cell types that are segregated into layers and functionally
distinct areas. To investigate the diversity of cell types across the mouse neocortex, here …

Elucidating the cellular architecture of the human cerebral cortex is central to understanding
our cognitive abilities and susceptibility to disease. Here we used single-nucleus RNA-…