User profiles for M. Gymrek
 | Melissa GymrekAssistant Professor, University of California San Diego Verified email at ucsd.edu Cited by 8486 |
Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences
We report the sequences of 1,244 human Y chromosomes randomly ascertained from 26
worldwide populations by the 1000 Genomes Project. We discovered more than 65,000 …
worldwide populations by the 1000 Genomes Project. We discovered more than 65,000 …
The Simons genome diversity project: 300 genomes from 142 diverse populations
Here we report the Simons Genome Diversity Project data set: high quality genomes from 300
individuals from 142 diverse populations. These genomes include at least 5.8 million base …
individuals from 142 diverse populations. These genomes include at least 5.8 million base …
A genomic view of short tandem repeats
M Gymrek - Current opinion in genetics & development, 2017 - Elsevier
Short tandem repeats (STRs) are some of the fastest mutating loci in the genome. Tools for
accurately profiling STRs from high-throughput sequencing data have enabled genome-wide …
accurately profiling STRs from high-throughput sequencing data have enabled genome-wide …
Identifying personal genomes by surname inference
Sharing sequencing data sets without identifiers has become a common practice in genomics.
Here, we report that surnames can be recovered from personal genomes by profiling …
Here, we report that surnames can be recovered from personal genomes by profiling …
[HTML][HTML] The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism
C Sebastián, BMM Zwaans, DM Silberman, M Gymrek… - Cell, 2012 - cell.com
Reprogramming of cellular metabolism is a key event during tumorigenesis. Despite being
known for decades (Warburg effect), the molecular mechanisms regulating this switch …
known for decades (Warburg effect), the molecular mechanisms regulating this switch …
Mutation and selection processes regulating short tandem repeats give rise to genetic and phenotypic diversity across species
…, Y Jin, M Anisimova, M Gymrek… - Journal of …, 2023 - academic.oup.com
… STRs are estimated to contribute to 10%–15% of heritable variation in gene expression in
humans due to common cis variants according to the findings in Gymrek et al. (2016). In the …
humans due to common cis variants according to the findings in Gymrek et al. (2016). In the …
[PDF][PDF] EWS-FLI1 utilizes divergent chromatin remodeling mechanisms to directly activate or repress enhancer elements in Ewing sarcoma
The aberrant transcription factor EWS-FLI1 drives Ewing sarcoma, but its molecular function
is not completely understood. We find that EWS-FLI1 reprograms gene regulatory circuits in …
is not completely understood. We find that EWS-FLI1 reprograms gene regulatory circuits in …
[HTML][HTML] Combinatorial patterning of chromatin regulators uncovered by genome-wide location analysis in human cells
Hundreds of chromatin regulators (CRs) control chromatin structure and function by catalyzing
and binding histone modifications, yet the rules governing these key processes remain …
and binding histone modifications, yet the rules governing these key processes remain …
Abundant contribution of short tandem repeats to gene expression variation in humans
… of ±M bp from the STR boundaries, where M was set to 1,000 for all marks except p300, for
which M was set to 200. Previous findings of GERV showed that these values of M give the …
which M was set to 200. Previous findings of GERV showed that these values of M give the …
lobSTR: a short tandem repeat profiler for personal genomes
Short tandem repeats (STRs) have a wide range of applications, including medical genetics,
forensics, and genetic genealogy. High-throughput sequencing (HTS) has the potential to …
forensics, and genetic genealogy. High-throughput sequencing (HTS) has the potential to …