Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes
of complex organisms. The term ‘lncRNAs’ encompasses RNA polymerase I (Pol I), Pol II …

It is clear that RNA has a diverse set of functions and is more than just a messenger between
gene and protein. The mammalian genome is extensively transcribed, giving rise to …

… Guttman, M. et al. Ab initio reconstruction of cell type-specific transcriptomes in mouse reveals
the … & Goodson, M. Stampy: a statistical algorithm for sensitive and fast mapping of Illumina …

… Guttman performed molecular biology experiments. All data analyses were performed by
M. Guttman in conjunction with M. Garber (conservation analyses), MFL (codon substitution …

Although thousands of large intergenic non-coding RNAs (lincRNAs) have been identified
in mammals, few have been functionally characterized, leading to debate about their …

We recently showed that the mammalian genome encodes >1,000 large intergenic
noncoding (linc)RNAs that are clearly conserved across mammals and, thus, functional. Gene …

Recently, more than 1000 large intergenic noncoding RNAs (lincRNAs) have been reported.
These RNAs are evolutionarily conserved in mammalian genomes and thus presumably …

The Unified Huntington's Disease Rating Scale (UHDRS) was developed as a clinical rating
scale to assess four domains of clinical performance and capacity in HD: motor function, …

… M. Garber provided source code for multiple alignment tracks. This work was supported
by The National Institute of General Medical Sciences (R01GM074024), National Cancer …

… M. Guttman and M. Garber conceived the project, designed research, implemented Scripture,
performed computational analysis and wrote the paper. AG, CN and JZL oversaw cDNA …