There is tremendous interest in using association mapping to identify genes responsible for
quantitative variation of complex traits with agricultural and evolutionary importance. Recent …

A major challenge for crop research in the 21st century is how to predict crop performance
as a function of genetic architecture. Advances in “next generation” DNA sequencing have …

Background In the 5 years that have passed since the publication of the 2018 International
Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (ICAR‐Allergic Rhinitis …

Background We conducted a phase 3, randomized, double-blind, placebo-controlled trial of
sorafenib, a multikinase inhibitor of tumor-cell proliferation and angiogenesis, in patients …

Background Intratumor heterogeneity may foster tumor evolution and adaptation and hinder
personalized-medicine strategies that depend on results from single tumor-biopsy samples. …

… receive either oral temozolomide at a starting dosage of 200 mg/m 2 /d for 5 days every 28
days or intravenous (IV) DTIC at a starting dosage of 250 mg/m 2 /d for 5 days every 21 days. …

A dosage formula has been derived from a retrospective analysis of carboplatin pharmacokinetics
in 18 patients with pretreatment glomerular filtration rates (GFR) in the range of 33 to …

… In conclusion, M-seq identified heterogeneous genomic landscapes and branched evolution
for each of ten sporadic VHL-deficient ccRCCs with spatially separated subclones, creating …

Background The treatment of advanced renal cell carcinoma has been revolutionised by
targeted therapy with drugs that block angiogenesis. So far, no phase 3 randomised trials …

Software programs that conduct genome-wide association studies and genomic prediction
and selection need to use methodologies that maximize statistical power, provide high …