[HTML][HTML] Invited review: Genomic selection in dairy cattle: Progress and challenges
…, PJ Bowman, AJ Chamberlain, ME Goddard - Journal of dairy …, 2009 - Elsevier
A new technology called genomic selection is revolutionizing dairy cattle breeding. Genomic
selection refers to selection decisions based on genomic breeding values (GEBV). The …
selection refers to selection decisions based on genomic breeding values (GEBV). The …
Scaling up from gardens: biodiversity conservation in urban environments
As urbanisation increases globally and the natural environment becomes increasingly
fragmented, the importance of urban green spaces for biodiversity conservation grows. In many …
fragmented, the importance of urban green spaces for biodiversity conservation grows. In many …
Genomic selection
ME Goddard, BJ Hayes - Journal of Animal breeding and …, 2007 - Wiley Online Library
… The use of multiple marker genotypes but without deducing haplotypes, eg with multiple
marker regression, will be in between these two extremes (Goddard 1991). Typically there are …
marker regression, will be in between these two extremes (Goddard 1991). Typically there are …
Prediction of total genetic value using genome-wide dense marker maps
THE Meuwissen, BJ Hayes, ME Goddard - genetics, 2001 - academic.oup.com
… a 30-M genome will be similar to those of Table 2. When going from a 1-M genome (in
preliminary tests of the programs) to 10-M … (although the 1-M results were more variable because …
preliminary tests of the programs) to 10-M … (although the 1-M results were more variable because …
[PDF][PDF] GCTA: a tool for genome-wide complex trait analysis
For most human complex diseases and traits, SNPs identified by genome-wide association
studies (GWAS) explain only a small fraction of the heritability. Here we report a user-friendly …
studies (GWAS) explain only a small fraction of the heritability. Here we report a user-friendly …
Common SNPs explain a large proportion of the heritability for human height
SNPs discovered by genome-wide association studies (GWASs) account for only a small
fraction of the genetic variation of complex traits in human populations. Where is the remaining …
fraction of the genetic variation of complex traits in human populations. Where is the remaining …
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
…, N Amin, AL Dixon, E Fisher, NL Glazer, ME Goddard… - Nature …, 2010 - nature.com
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …
Hundreds of variants clustered in genomic loci and biological pathways affect human height
…, J Luan, G Thorleifsson, TW Winkler, ME Goddard… - Nature, 2010 - nature.com
Most common human traits and diseases have a polygenic pattern of inheritance: DNA
sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA…
sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA…
Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets
Genome-wide association studies (GWAS) have identified thousands of genetic variants
associated with human complex traits. However, the genes or functional DNA elements through …
associated with human complex traits. However, the genes or functional DNA elements through …
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
…, RH Perlis, BJ Mowry, A Thapar, ME Goddard… - Nature …, 2013 - cdr.lib.unc.edu
Most psychiatric disorders are moderately to highly heritable. The degree to which genetic
variation is unique to individual disorders or shared across disorders is unclear. To examine …
variation is unique to individual disorders or shared across disorders is unclear. To examine …