… Matthew Gentzel completed his contributions while contracting for OpenAI, and is now at
Longview Philanthropy. Katerina Sedova completed her contributions to this project while she …

Major structural changes occur in the spliceosome during its activation just before catalyzing
the splicing of pre–messenger RNAs (pre-mRNAs). Whereas changes in small nuclear …

… RNA and protein were recovered and analyzed on 8.3 M urea/10% polyacrylamide gels (…
RNA was recovered (12) and resolved on a 5% polyacrylamide/8.3 M urea gel and analyzed by …

Mass spectrometry was used to identify novel proteins associated with the human 17S U2
snRNP and one of its stable subunits, SF3b. Several additional proteins were identified, …

… h, washed with 0.5 M NaCl in PBS, and eluted with 0.2 M glycine and 0.15 M NaCl (pH 2.3).
… Ellenberg, M. Wilm and all members of the Mattaj lab for critical discussion of the manuscript…

In metazoa, the nuclear envelope breaks down and reforms during each cell cycle. Nuclear
pore complexes (NPCs), which serve as channels for transport between the nucleus and …

The ensemble of expressed proteins in a given cell is organized in multiprotein complexes 1
, 2 . The identification of the individual components of these complexes is essential for their …

During catalytic activation of the spliceosome, snRNP remodeling events occur, leading to
the formation of a 35S U5 snRNP that contains a large group of proteins, including Prp19 and …

Connexins are the primary components of gap junctions, providing direct links between
cells under many physiological processes. Here, we demonstrate that in addition to this …

Dosage compensation, mediated by the MSL complex, regulates X-chromosomal gene
expression in Drosophila. Here we report that the histone H4 lysine 16 (H4K16) specific histone …