Ischemic stroke is a major cause of death. Besides the direct damage resulting from oxygen
and glucose deprivation, sterile inflammation plays a pivotal role in increasing cellular death…

CC chemokine receptor 2 (CCR2) plays important roles in extravasation and transmigration
of monocytes under inflammatory conditions. CCR2 and its ligands have been extensively …

Background and Purpose— Ischemic stroke leads to significant morbidity and mortality in the
Western world. Early reperfusion strategies remain the treatment of choice but can initiate …

The devastating effect of ischemic stroke is attenuated in mice lacking conventional and
unconventional T cells, suggesting that inflammation enhances tissue damage in cerebral …

Multi-protein complexes called inflammasomes have recently been identified and shown to
contribute to cell death in tissue injury. Intravenous immunoglobulin (IVIg) is an FDA-…

Dendritic cells (DCs) are professional antigen presenting cells that constantly survey the
environment acting as sentinels of the immune system, including in the CNS. DCs are …

We tested whether significant leukocyte infiltration occurs in a mouse model of permanent
cerebral ischemia. C57BL6/J male mice underwent either permanent (3 or 24 hours) or …

Background Patients with encephalitis associated with antibodies against N-methyl-D-aspartate-receptor
antibody (NMDAR-ab) encephalitis frequently show psychotic symptoms, …

… After washing the pellet three times, it was dried in room temperature and suspended in
200 μl of laemmli buffer and 20ul of 1 M Tris (pH 8) and heated at 95 C. Protein concentration …

Background and Purpose— Brain injury during stroke results in oxidative stress and the
release of factors that include extracellular Ca 2+ , hydrogen peroxide, adenosine diphosphate …