Background Immunohistochemical markers are often used to classify breast cancer into
subtypes that are biologically distinct and behave differently. The aim of this study was to …

Context Approximately 10% of women with invasive epithelial ovarian cancer (EOC) carry
deleterious germline mutations in BRCA1 or BRCA2. A recent article suggested that BRCA2 -…

Background Many reported associations between common genetic polymorphisms and
complex diseases have not been confirmed in subsequent studies. An exception could be the …

Age at menarche is a marker of timing of puberty in females. It varies widely between
individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, …

Abstract Analysis of gene expression data suggests that breast cancers are divisible into
molecular subtypes which have distinct clinical features. This study evaluates whether …

Abstract Knowledge of genetics and its implications for human health is rapidly evolving in
accordance with recent events, such as discoveries of large numbers of disease susceptibility …

Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility
to the disease. Known susceptibility genes account for less than 25% of the familial risk of …

Menopause timing has a substantial impact on infertility and risk of disease, including breast
cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in …

Background Few biomarkers of ovarian cancer prognosis have been established, partly
because subtype-specific associations might be obscured in studies combining all …

We conducted a multi-stage, genome-wide association study of bladder cancer with a
primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of …