User profiles for M. Ganapathiraju

Madhavi Ganapathiraju

Associate Professor of Biomedical Informatics and Intelligent Systems, University of …
Verified email at pitt.edu
Cited by 2732

Global genetic analysis in mice unveils central role for cilia in congenital heart disease

…, R Francis, L Leatherbury, MK Ganapathiraju… - Nature, 2015 - nature.com
… mutant (m/+) showed the expected 514 bp wild-type and 271 bp mutant PCR product,
while only the 271 bp mutant product was observed in the homozygous mutant (m/m) sample. …

Everything you wanted to know about smart health care: Evaluating the different technologies and components of the internet of things for better health

…, SP Mohanty, MK Ganapathiraju - IEEE consumer …, 2017 - ieeexplore.ieee.org
The Internet-of-Things (IoT) has taken over the business spectrum, and its applications vary
widely from agriculture and health care to transportation. A hospital environment can be very …

[HTML][HTML] Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor

…, JL Schmid-Burgk, T Schmidt, MK Ganapathiraju… - Immunity, 2014 - cell.com
Virus infection is sensed in the cytoplasm by retinoic acid-inducible gene I (RIG-I, also known
as DDX58), which requires RNA and polyubiquitin binding to induce type I interferon (IFN) …

The complex genetics of hypoplastic left heart syndrome

…, D Kostka, KL de Mesy Bentley, MK Ganapathiraju… - Nature …, 2017 - nature.com
m/m ; Pcdha9 m/m mutants. Penetrance decreased by half in Sap130 m/m ; Pcdha9 m/+
mutants and ninefold in Sap130 m/m ; … observed in only Sap130 m/m mutants (Table 1). Pcdha9 …

Learning structure in gene expression data using deep architectures, with an application to gene clustering

…, H Wang, M Ganapathiraju - 2015 IEEE international …, 2015 - ieeexplore.ieee.org
Genes play a central role in all biological processes. DNA microarray technology has made
it possible to study the expression behavior of thousands of genes in one go. Often, gene …

[PDF][PDF] Uncompensated mitochondrial oxidative stress underlies heart failure in an iPSC-derived model of congenital heart disease

…, D Kostka, GS Pryhuber, S Shiva, MK Ganapathiraju… - Cell Stem Cell, 2022 - cell.com
Hypoplastic left heart syndrome (HLHS) is a severe congenital heart disease with 30% mortality
from heart failure (HF) in the first year of life, but the cause of early HF remains unknown. …

[HTML][HTML] Retinitis pigmentosa associated with rhodopsin mutations: Correlation between phenotypic variability and molecular effects

…, D Man, N Waseem, BJ Jennings, M Ganapathiraju… - Vision research, 2006 - Elsevier
… The flash intensities in cd s/m 2 are given to the left of each response. DA = dark-adapted; …
to a standard mixed flash of 0.18 cd s/m 2 (also illustrated in the Supplementary figure). …

[HTML][HTML] Schizophrenia interactome with 504 novel protein–protein interactions

MK Ganapathiraju, M Thahir, A Handen, SN Sarkar… - NPJ …, 2016 - nature.com
Genome-wide association studies of schizophrenia (GWAS) have revealed the role of rare
and common genetic variants, but the functional effects of the risk variants remain to be …

[HTML][HTML] Wiki-pi: a web-server of annotated human protein-protein interactions to aid in discovery of protein function

N Orii, MK Ganapathiraju - PloS one, 2012 - journals.plos.org
Protein-protein interactions (PPIs) are the basis of biological functions. Knowledge of the
interactions of a protein can help understand its molecular function and its association with …

[HTML][HTML] Benchmark evaluation of protein–protein interaction prediction algorithms

B Dunham, MK Ganapathiraju - Molecules, 2021 - mdpi.com
… Thahir, M.; Sharma, T.; Ganapathiraju, MK An efficient heuristic method for active feature
acquisition and its application to protein-protein interaction prediction. In Proceedings of the …