Over the past decade, we have observed a massive increase in the amount of information
describing protein sequences from a variety of organisms. 1, 2 While this may reflect the …

Cellular compartments and organelles organize biological matter. Most well-known organelles
are separated by a membrane boundary from their surrounding milieu. There are also …

The notion that all protein functions are determined through macromolecular interactions is
the driving force behind current efforts that aim to solve the structures of all cellular complexes…

Type II restriction endonucleases are components of restriction modification systems that
protect bacteria and archaea against invading foreign DNA. Most are homodimeric or …

… : Q i = 100 N obs ,i M ii where N obs,i is the number of residues observed in conformational
state i, calculated as N obs ,i = ∑ j=1 3 M ij , where j runs over all three conformational states. …

Alternative inclusion of exons increases the functional diversity of proteins. Among alternatively
spliced exons, tissue-specific exons play a critical role in maintaining tissue identity. This …

Motivation: The dynamic nature of protein interaction networks requires fast and transient
molecular switches. The underlying recognition motifs (linear motifs, LMs) are usually short and …

The MobiDB database (URL: https://mobidb.org/ ) provides predictions and annotations for
intrinsically disordered proteins. Here, we report recent developments implemented in …

A wide range of proteins have been reported to condensate into a dense liquid phase,
forming a reversible droplet state. Failure in the control of the droplet state can lead to the …

“What’s in a name? That which we call a rose By any other name would smell as sweet.”
From “Romeo and Juliet”, William Shakespeare (1594) This article opens a series of …