User profiles for M. El-Kebir
Mohammed El-KebirAssistant Professor Verified email at illinois.edu Cited by 1963 |
Multiscale computational modeling reveals a critical role for TNF-α receptor 1 dynamics in tuberculosis granuloma formation
… Finally, our model elucidates processes involved in immunity to M. tuberculosis that may be
… We develop a multiscale computational model that describes the immune response to M. …
… We develop a multiscale computational model that describes the immune response to M. …
Reconstruction of clonal trees and tumor composition from multi-sample sequencing data
… m samples from a tumor with n mutations sites. Our observations are then described by an m
× … We define an m × n usage matrix U = [ u p i ] , where u pi indicates the fraction of cells in …
× … We define an m × n usage matrix U = [ u p i ] , where u pi indicates the fraction of cells in …
Charge group partitioning in biomolecular simulation
… Does there exist a perfect matching in (ie, a subset of m triples such that each element of X …
Now, since there exists no perfect matching, we need m + c groups of type 1, 2, or 3, for some …
Now, since there exists no perfect matching, we need m + c groups of type 1, 2, or 3, for some …
[PDF][PDF] Inferring the mutational history of a tumor using multi-state perfect phylogeny mixtures
… We represent our input measurements by a k 3 m 3 n frequency tensor F = ½½fp,ðc,iÞ . We
denote the root vertex of T by vðÃ,0Þ and the remaining vertices by vðc,iÞ, where i is the new …
denote the root vertex of T by vðÃ,0Þ and the remaining vertices by vðc,iÞ, where i is the new …
Inferring parsimonious migration histories for metastatic cancers
… Suppose we measure all clones that are present in m anatomical sites of a metastatic cancer.
These clones are distinguished by their somatic mutations and their anatomical locations. …
These clones are distinguished by their somatic mutations and their anatomical locations. …
SPhyR: tumor phylogeny estimation from single-cell sequencing data under loss and error
M El-Kebir - Bioinformatics, 2018 - academic.oup.com
… We consider a tumor composed of m cells that contain n SNVs. In the following, we refer
to … We represent the cell division and mutation history of the m tumor cells by a character-based …
to … We represent the cell division and mutation history of the m tumor cells by a character-based …
A hybrid multi-compartment model of granuloma formation and T cell priming in tuberculosis
… To capture this in the model, we define the sum of infected (M I ) and chronically infected
macrophages (M CI ) in the granuloma lung compartment at time t as a proxy for the number of …
macrophages (M CI ) in the granuloma lung compartment at time t as a proxy for the number of …
Lagrangian relaxation applied to sparse global network alignment
Data on molecular interactions is increasing at a tremendous pace, while the development
of solid methods for analyzing this network data is lagging behind. This holds in particular for …
of solid methods for analyzing this network data is lagging behind. This holds in particular for …
Design of SARS-CoV-2 variant-specific pcr assays considering regional and temporal characteristics
Monitoring the prevalence of SARS-CoV-2 variants is necessary to make informed public
health decisions during the COVID-19 pandemic. PCR assays have received global attention, …
health decisions during the COVID-19 pandemic. PCR assays have received global attention, …
Summarizing the solution space in tumor phylogeny inference by multiple consensus trees
N Aguse, Y Qi, M El-Kebir - Bioinformatics, 2019 - academic.oup.com
… We require that R s is a spanning arborescence of the vertex set [ m ] , ie R s contains a
single vertex p that does not have a parent. To indicate the root vertex, we introduce variables z …
single vertex p that does not have a parent. To indicate the root vertex, we introduce variables z …