User profiles for M. El-Kebir

Mohammed El-Kebir

Assistant Professor
Verified email at illinois.edu
Cited by 1963

Multiscale computational modeling reveals a critical role for TNF-α receptor 1 dynamics in tuberculosis granuloma formation

M Fallahi-Sichani, M El-Kebir, S Marino… - The Journal of …, 2011 - journals.aai.org
… Finally, our model elucidates processes involved in immunity to M. tuberculosis that may be
… We develop a multiscale computational model that describes the immune response to M. …

Reconstruction of clonal trees and tumor composition from multi-sample sequencing data

M El-Kebir, L Oesper, H Acheson-Field… - …, 2015 - academic.oup.com
m samples from a tumor with n mutations sites. Our observations are then described by an m
× … We define an m × n usage matrix U = [ u p i ] ⁠, where u pi indicates the fraction of cells in …

Charge group partitioning in biomolecular simulation

S Canzar, M El-Kebir, R Pool, K Elbassioni… - Journal of …, 2013 - liebertpub.com
… Does there exist a perfect matching in (ie, a subset of m triples such that each element of X …
Now, since there exists no perfect matching, we need m + c groups of type 1, 2, or 3, for some …

[PDF][PDF] Inferring the mutational history of a tumor using multi-state perfect phylogeny mixtures

M El-Kebir, G Satas, L Oesper, BJ Raphael - Cell systems, 2016 - cell.com
… We represent our input measurements by a k 3 m 3 n frequency tensor F = ½½fp,ðc,iÞ . We
denote the root vertex of T by vðÃ,0Þ and the remaining vertices by vðc,iÞ, where i is the new …

Inferring parsimonious migration histories for metastatic cancers

M El-Kebir, G Satas, BJ Raphael - Nature genetics, 2018 - nature.com
… Suppose we measure all clones that are present in m anatomical sites of a metastatic cancer.
These clones are distinguished by their somatic mutations and their anatomical locations. …

SPhyR: tumor phylogeny estimation from single-cell sequencing data under loss and error

M El-Kebir - Bioinformatics, 2018 - academic.oup.com
… We consider a tumor composed of m cells that contain n SNVs. In the following, we refer
to … We represent the cell division and mutation history of the m tumor cells by a character-based …

A hybrid multi-compartment model of granuloma formation and T cell priming in tuberculosis

S Marino, M El-Kebir, D Kirschner - Journal of theoretical biology, 2011 - Elsevier
… To capture this in the model, we define the sum of infected (M I ) and chronically infected
macrophages (M CI ) in the granuloma lung compartment at time t as a proxy for the number of …

Lagrangian relaxation applied to sparse global network alignment

M El-Kebir, J Heringa, GW Klau - … , Delft, The Netherlands, November 2-4 …, 2011 - Springer
Data on molecular interactions is increasing at a tremendous pace, while the development
of solid methods for analyzing this network data is lagging behind. This holds in particular for …

Design of SARS-CoV-2 variant-specific pcr assays considering regional and temporal characteristics

…, P Sashittal, A Zhou, L Wang, M El-Kebir… - Applied and …, 2022 - Am Soc Microbiol
Monitoring the prevalence of SARS-CoV-2 variants is necessary to make informed public
health decisions during the COVID-19 pandemic. PCR assays have received global attention, …

Summarizing the solution space in tumor phylogeny inference by multiple consensus trees

N Aguse, Y Qi, M El-Kebir - Bioinformatics, 2019 - academic.oup.com
… We require that R s is a spanning arborescence of the vertex set [ m ] ⁠, ie R s contains a
single vertex p that does not have a parent. To indicate the root vertex, we introduce variables z …