… As the manuscript was being finalized, a meeting was held at NCEAS on “Phylogenies and
Community Ecology” (organized by Donoghue & Webb), and we valued the opportunity to …

Ecology and historical (phylogeny-based) biogeography have much to offer one another, but
exchanges between these fields have been limited. Historical biogeography has become …

The FDA approved pembrolizumab on June 16, 2020, for the treatment of adult and
pediatric patients with unresectable or metastatic tumor mutational burden–high [TMB-H; ≥10 …

We integrated the genomic sequencing of 1,918 breast cancers, including 1,501 hormone
receptor-positive tumors, with detailed clinical information and treatment outcomes. In 692 …

Metastatic progression is the main cause of death in cancer patients, whereas the underlying
genomic mechanisms driving metastasis remain largely unknown. Here, we assembled …

… Incubation of Ang1-9 with ACE in vitro generated Ang1-7 (m/z 899.47) and Ang1-5 (m/z
665.36), apparently by sequential cleavage of C-terminal dipeptides (Figure 8). Conversion to …

RNA interference (RNAi) holds considerable promise as a therapeutic approach to silence
disease-causing genes, particularly those that encode so-called ‘non-druggable’ targets that …

… of the other pair of orthologues in the direct sequences, eg, by sequence divergence between
the two classes of repeat-types at a primer annealing-site used by Baldwin & Donoghue. If …

Although p53 inactivation promotes genomic instability 1 and presents a route to malignancy
for more than half of all human cancers 2 , 3 , the patterns through which heterogenous …

Methods that use outgroups in the reconstruction of phylogeny are described and evaluated
by the criterion of parsimony. By considering the character states and relationships of …