Two major theories of schizophrenia are respectively, the neurodevelopmental hypothesis
and the dopamine hypothesis. Each of these has recently been revised. Firstly, the classical …

Objectives The liberalisation of cannabis laws, the increasing availability and potency of
cannabis has renewed concern about the risk of psychosis with cannabis. Methods The …

Background The risk of individuals having adverse effects from drug use (eg, alcohol) generally
depends on the frequency of use and potency of the drug used. We aimed to investigate …

BackgroundPeople who use cannabis have an increased risk of psychosis an effect attributed
to the active ingredient δ9-tetrahydrocannabinol (Δ9-THC). There has recently been …

By analyzing the whole-exome sequences of 4,264 schizophrenia cases, 9,343 controls
and 1,077 trios, we identified a genome-wide significant association between rare loss-of-…

Cannabis use has been reported to induce long-lasting psychotic disorders and a dose-response
relationship has been observed. We performed a systematic review of studies that …

The integrity of brain white matter connections is central to a patient’s ability to respond to
pharmacological interventions. This study tested this hypothesis using a specific measure of …

Background Although cannabis use after a first episode of psychosis has been associated
with relapse, little is known about the determinants of this most preventable risk factor for …

Importance At present, no reliable predictors exist to distinguish future responders from
nonresponders to treatment during the first episode of psychosis. Among potential neuroimaging …

BackgroundThe high incidence of the metabolic syndrome in patients with psychosis is mainly
attributed to antipsychotic treatment. However, it is also possible that psychological stress …