Cannabis use has been reported to induce long-lasting psychotic disorders and a dose-response
relationship has been observed. We performed a systematic review of studies that …

Cannabis use is considered a contributory cause of schizophrenia and psychotic illness.
However, only a small proportion of cannabis users develop psychosis. This can partly be …

Background and aims Cannabis products with high delta‐9‐tetrahydrocannabinol (THC)
concentrations carry an increased risk of addiction and mental health disorders, while it has …

Reduced fecundity, associated with severe mental disorders 1 , places negative selection
pressure on risk alleles and may explain, in part, why common variants have not been found …

Background Cannabis use is associated with increased risk of later psychotic disorder but
whether it affects incidence of the disorder remains unclear. We aimed to identify patterns of …

Background The risk of individuals having adverse effects from drug use (eg, alcohol) generally
depends on the frequency of use and potency of the drug used. We aimed to investigate …

BackgroundPeople who use cannabis have an increased risk of psychosis an effect attributed
to the active ingredient δ9-tetrahydrocannabinol (Δ9-THC). There has recently been …

Schizophrenia and bipolar disorder are two distinct diagnoses that share symptomology.
Understanding the genetic factors contributing to the shared and disorder-specific symptoms …

Cannabis use is associated with an earlier age of onset of psychosis (AOP). However, the
reasons for this remain debated. Methods: We applied a Cox proportional hazards model to …

First-episode psychosis (FEP) patients show hyperactivity of the hypothalamic–pituitary–adrenal
(HPA) axis, but the mechanisms leading to this are still unclear. The aim of this study …