Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous
studies; however, a large portion of the genetic risk for this disease remains unexplained. …

Risk for late-onset Alzheimer’s disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association …

Apolipoprotein E (APOE) dependent lifetime risks (LTRs) for Alzheimer Disease (AD) are
currently not accurately known and odds ratios alone are insufficient to assess these risks. We …

Adverse drug reactions (ADRs) are a significant cause of morbidity and mortality. The
majority of ADRs can be considered common disorders with considerable clinical variability (…

Background Lithium is a first-line treatment in bipolar disorder, but individual response is
variable. Previous studies have suggested that lithium response is a heritable trait. However, …

Background There is an emerging interest in the use of cellular models to study psychiatric
disorders. We have systematically reviewed the application of cellular models to understand …

Background Environmental conditions early in life may imprint the circadian system and
influence response to environmental signals later in life. We previously determined that a large …

Bipolar disorder (BD) is a genetically complex mental illness characterized by severe
oscillations of mood and behaviour. Genome-wide association studies (GWAS) have identified …

For more than half a decade, lithium has been successfully used to treat bipolar disorder.
Worldwide, it is considered the first-line mood stabilizer. Apart from its proven antimanic and …

Background Late‐onset Alzheimer's disease (AD) is heritable with 20 genes showing
genome‐wide association in the International Genomics of Alzheimer's Project (IGAP). To identify …