The field of epigenomics has rapidly progressed from the study of individual reference
epigenomes to surveying epigenomic variation in populations. Recent studies in a number of …

Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract infection, however,
a subset of patients progress to severe disease and respiratory failure. The mechanism …

Longitudinal analyses of the innate immune system, including the earliest time points, are
essential to understand the immunopathogenesis and clinical course of coronavirus disease (…

Growing evidence shows that epigenetic mechanisms contribute to complex traits, with
implications across many fields of biology. In plant ecology, recent studies have attempted to …

Histone 3 K4 trimethylation (depositing H3K4me3 marks) is typically associated with active
promoters yet paradoxically occurs at untranscribed domains. Research to delineate the …

Histones are highly covalently modified, but the functions of many of these modifications
remain unknown. In particular, it is unclear how histone marks are coupled to cellular …

Background Chromosome instability leads to aneuploidy, a state in which cells have abnormal
numbers of chromosomes, and is found in two out of three cancers. In a chromosomal …

Single cell high throughput genomic measurements are revolutionizing the fields of biology
and medicine, providing a means to tackle biological problems that have thus far been …

… Here, X i denotes the integration output for run i and M bio and M batch denote the set of
metrics that contribute to the bio-conservation and batch removal scores, respectively. …

Background Genomic imprinting is an epigenetic phenomenon that allows a subset of genes
to be expressed mono-allelically based on the parent of origin and is typically regulated by …