Phosphoinositide 3-kinase δ gene mutation predisposes to respiratory infection and airway damage
Genetic mutations cause primary immunodeficiencies (PIDs) that predispose to infections.
Here, we describe activated PI3K-δ syndrome (APDS), a PID associated with a dominant gain-…
Here, we describe activated PI3K-δ syndrome (APDS), a PID associated with a dominant gain-…
FcγRIIB in autoimmunity and infection: evolutionary and therapeutic implications
KGC Smith, MR Clatworthy - Nature Reviews Immunology, 2010 - nature.com
FcγRIIB is the only inhibitory Fc receptor. It controls many aspects of immune and inflammatory
responses, and variation in the gene encoding this protein has long been associated with …
responses, and variation in the gene encoding this protein has long been associated with …
The use of structural allograft for uncontained defects in revision total knee arthroplasty: a minimum five-year review
MG Clatworthy, J Ballance, GW Brick, HP Chandler… - JBJS, 2001 - journals.lww.com
Background: To our knowledge, the medium to long-term outcome after revision knee arthroplasty
with structural allograft augmentation for reconstruction of uncontained defects has not …
with structural allograft augmentation for reconstruction of uncontained defects has not …
The human cell atlas
10.7554/eLife.27041.001 The recent advent of methods for high-throughput single-cell
molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe …
molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe …
[HTML][HTML] Single-cell multi-omics analysis of the immune response in COVID-19
Abstract Analysis of human blood immune cells provides insights into the coordinated
response to viral infections such as severe acute respiratory syndrome coronavirus 2, which …
response to viral infections such as severe acute respiratory syndrome coronavirus 2, which …
Cross-tissue immune cell analysis reveals tissue-specific features in humans
Despite their crucial role in health and disease, our knowledge of immune cells within human
tissues remains limited. We surveyed the immune compartment of 16 tissues from 12 adult …
tissues remains limited. We surveyed the immune compartment of 16 tissues from 12 adult …
Financial reporting of good news and bad news: evidence from accounting narratives
M Clatworthy, MJ Jones - Accounting and business research, 2003 - Taylor & Francis
Accounting narratives are an increasingly important medium of financial communication. In
particular, they play a crucial role in the corporate annual report, allowing company …
particular, they play a crucial role in the corporate annual report, allowing company …
Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors
… Gessler, and M. Ramakrishna for review of the manuscript and M. Gerstung and V. Svensson
for … Ramakrishna for review of the manuscript and M. Gerstung and V. Svensson for advice …
for … Ramakrishna for review of the manuscript and M. Gerstung and V. Svensson for advice …
[HTML][HTML] Local and systemic responses to SARS-CoV-2 infection in children and adults
It is not fully understood why COVID-19 is typically milder in children 1 , 2 – 3 . Here, to examine
the differences between children and adults in their response to SARS-CoV-2 infection, …
the differences between children and adults in their response to SARS-CoV-2 infection, …
[HTML][HTML] The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation
N Subramanian, K Natarajan, MR Clatworthy, Z Wang… - Cell, 2013 - cell.com
NLRP3 is a key component of the macromolecular signaling complex called the inflammasome
that promotes caspase 1-dependent production of IL-1β. The adaptor ASC is necessary …
that promotes caspase 1-dependent production of IL-1β. The adaptor ASC is necessary …