Until recently, dynein was the least understood of the cytoskeletal motors. However, a
wealth of new structural, mechanistic, and cell biological data is shedding light on how this …

… Author links open overlay panel Philip R Baldwin 1 , Yong Zi Tan 1 2 , Edward T Eng 1 ,
William J Rice 1 , Alex J Noble 1 , Carl J Negro 1 , Michael A Cianfrocco 3 , Clinton S Potter 1 2 , …

… Cianfrocco… Cianfrocco … As the required distances can reach up to 1 m in length, the
creation, transport, and positioning of mitochondria is a formidable task for the neuron. …

Human cytomegalovirus (HCMV) is a major cause of morbidity and mortality in transplant
patients and the leading viral cause of birth defects after congenital infection. The glycoprotein …

… with 0.3 M NaCl, EB with 1 M NaCl, EB with 0.3 M NaCl and finally EB. The efficiency of
elongation complex assembly and bead association was estimated to be 20–50% based on the …

A mechanistic description of metazoan transcription is essential for understanding the
molecular processes that govern cellular decisions. To provide structural insights into the DNA …

… In vitro dicing assays have shown that human Dicer processes a 35-bp pre-siRNA (37ab)
with maximal cleavage rates (k cat /K m ) that are two orders of magnitude slower than those …

… As before, a single Lis1 b-propeller was bound to Dynwt-M, even though Lis1 was present
as a … Our map of Dynwt-M:Lis1 appears to show the linker in its pre-power stroke position; …

1 Structural biology is in the midst of a revolution. Instrumentation and software improvements
have allowed for the full realization of cryo-electron microscopy (cryo-EM) as a tool …

Mitochondria are the main site for generating reactive oxygen species, which are key
players in diverse biological processes. However, the molecular pathways of redox signal …