Nanoconnectomic upper bound on the variability of synaptic plasticity

TM Bartol Jr, C Bromer, J Kinney, MA Chirillo… - elife, 2015 - elifesciences.org
10.7554/eLife.10778.001 Information in a computer is quantified by the number of bits that
can be stored and recovered. An important question about the brain is how much information …

Mitochondrial support of persistent presynaptic vesicle mobilization with age-dependent synaptic growth after LTP

HL Smith, JN Bourne, G Cao, MA Chirillo, LE Ostroff… - Elife, 2016 - elifesciences.org
10.7554/eLife.15275.001 Mitochondria support synaptic transmission through production of
ATP, sequestration of calcium, synthesis of glutamate, and other vital functions. Surprisingly, …

[HTML][HTML] Local resources of polyribosomes and SER promote synapse enlargement and spine clustering after long-term potentiation in adult rat hippocampus

MA Chirillo, MS Waters, LF Lindsey, JN Bourne… - Scientific reports, 2019 - nature.com
Synapse clustering facilitates circuit integration, learning, and memory. Long-term potentiation
(LTP) of mature neurons produces synapse enlargement balanced by fewer spines, …

Dynamics of nascent and active zone ultrastructure as synapses enlarge during long‐term potentiation in mature hippocampus

ME Bell, JN Bourne, MA Chirillo… - Journal of …, 2014 - Wiley Online Library
Nascent zones and active zones are adjacent synaptic regions that share a postsynaptic
density, but nascent zones lack the presynaptic vesicles found at active zones. Here dendritic …

Presynaptic ultrastructural plasticity along CA3→ CA1 axons during long‐term potentiation in mature hippocampus

JN Bourne, MA Chirillo… - Journal of Comparative …, 2013 - Wiley Online Library
In area CA1 of the mature hippocampus, synaptogenesis occurs within 30 minutes after the
induction of long‐term potentiation (LTP); however, by 2 hours many small dendritic spines …

Multicenter comparison of ESP Culture System II with BACTEC 460TB and with Lowenstein-Jensen medium for recovery of mycobacteria from different clinical …

E Tortoli, P Cichero, MG Chirillo… - Journal of clinical …, 1998 - Am Soc Microbiol
… Different media and systems appeared to behave differently when the more frequently
detected organisms were considered: M. tuberculosis complex isolates grew better with BACTEC, …

[HTML][HTML] Core concepts in physiology: teaching homeostasis through pattern recognition

M Chirillo, DU Silverthorn… - Advances in Physiology …, 2021 - journals.physiology.org
Homeostasis is a core concept in systems physiology that future clinicians and biomedical
professionals will apply in their careers. Despite this, many students struggle to transfer the …

Hippocampal spine head sizes are highly precise

TM Bartol, C Bromer, J Kinney, MA Chirillo, JN Bourne… - Biorxiv, 2015 - biorxiv.org
Hippocampal synaptic activity is probabilistic and because synaptic plasticity depends on its
history, the amount of information that can be stored at a synapse is limited. The strong …

Learning (by) osmosis: an approach to teaching osmolarity and tonicity

P Vujovic, M Chirillo… - Advances in physiology …, 2018 - journals.physiology.org
Understanding osmolarity and tonicity is one of the more challenging endeavors undertaken
by students of the natural sciences. We asked students who completed a course in animal …

Analysis of Escherichia coli Isolated from Patients Affected by Crohn's Disease

T Raso, S Crivellaro, MG Chirillo, P Pais, E Gaia… - Current …, 2011 - Springer
The etiopathogenesis of Crohn’s disease (CD) is still controversial: several genetic, immunologic,
and environmental factors, including some bacteria, have been implicated. This study …