Understanding the mechanisms that modulate helper T lymphocyte functions is crucial to
decipher normal and pathogenic immune responses in humans. To identify molecular …

The complexity of the proteome exceeds that of the genome. Post-translational modifications
(PTMs) and conformational changes of proteins trigger new molecular interactions whose …

MicroRNAs (miRNAs) are short RNA molecules that regulate gene expression post-transcriptionally.
They have emerged as important modulators of T lymphocyte biology, influencing …

Antibody libraries are important resources to derive antibodies to be used for a wide range
of applications, from structural and functional studies to intracellular protein interference …

Within the immune system, microRNAs (miRNAs) exert key regulatory functions. However,
what are the mRNA targets regulated by miRNAs and how miRNAs are transcriptionally …

Among Histone post-translational modifications (PTMs), lysine acetylation plays a pivotal role
in the epigenetic regulation of gene expression, mediated by chromatin modifying enzymes…

In mammals, the 5’‐methylcytosine (5mC) modification in the genomic DNA contributes to
the dynamic control of gene expression. 5mC erasure is required for the activation of …

… Chirichella performed all the experiments except for the integrase infectivity assay, which …
and tested intrabody proteins; M. Chirichella and MG performed H3 yeast screening; SL, M. …

Secondary trauma, also referred to as secondary traumatic stress disorder (STSD), refers to
the acquisition and experiencing of trauma symptoms as a result of close and extended …

Ex vivo gene expression and miRNA profiling of Eomes+ Tr1‐like cells suggested that they
represent a differentiation stage that is intermediate between Th1‐cells and cytotoxic CD4+ T…