Mitochondria are essential constituents of a eukaryotic cell by supplying ATP and contributing
to many mayor metabolic processes. As endosymbiotic organelles, they represent a …

Aβ peptides play a central role in the etiology of Alzheimer disease (AD) by exerting cellular
toxicity correlated with aggregate formation. Experimental evidence has shown …

… We then directly compared the effects of NOT4 or CCR4 deletion on K12‐M mRNA levels
and the levels of the corresponding translation arrest product in the absence of Ltn1. K12‐…

Aggregation processes can cause severe perturbations of cellular homeostasis and are
frequently associated with diseases. We performed a comprehensive analysis of mitochondrial …

Sorting of transmembrane proteins into the inner vesicles of multivesicular bodies for subsequent
delivery to the vacuole/lysosome can be induced by attachment of a single ubiquitin or …

Background Mesenchymal stem cells (MSCs) participate in the regulation of inflammation
and innate immunity, for example by responding to pathogen-derived signals and by …

… In human disease, three major MDSC subpopulations can be defined as monocytic (M-MDSC),
granulocytic [polymorphonuclear-MDSC (PMN-MDSC)], and early stage (e-MDSC), …

The interaction of mesenchymal stromal cells (MSCs) with natural killer (NK) cells is traditionally
thought of as a static inhibitory model, whereby resting MSCs inhibit NK cell effector …

Background The suppressive effect of mesenchymal stromal/stem cells (MSCs) on diverse
immune cells is well known, but it is unclear whether MSCs additionally possess …

… PMN)-MDSC exceeded the expansion of monocytic MDSC (M-MDSC) in five out of six solid
… Programmed death-ligand 1 was primarily expressed in M-MDSC and e-MDSC and was not …