Alternative polyadenylation (APA) is a general mechanism of transcript diversification in
mammals, which has been recently linked to proliferative states and cancer. Different 3′ …

Recent years have seen a boom in the application of the next‐generation sequencing technology
to the study of human disorders, including Autism Spectrum Disorder (ASD), where the …

Functional variomics provides the foundation for personalized medicine by linking genetic
variation to disease expression, outcome and treatment, yet its utility is dependent on …

A major challenge facing the genetics of autism spectrum disorders (ASDs) is the large and
growing number of candidate risk genes and gene variants of unknown functional …

Patch-seq, combining patch-clamp electrophysiology with single-cell RNA-sequencing (scRNAseq),
enables unprecedented access to a neuron's transcriptomic, electrophysiological, …

Vast amounts of transcriptomic data reside in public repositories, but effective reuse remains
challenging. Issues include unstructured dataset metadata, inconsistent data processing …

Autism spectrum disorder (ASD) is a highly heterogeneous genetic disorder with strong
evidence of ASD‐association currently available only for a small number of genes. This makes it …

With the recent expansion of Head-mounted virtual reality (VR) screens for consumers, many
sectors of industry have begun to recognize the high potential of VR. However, there has …

Identifying variants causal for complex genetic disorders is challenging. With the advent of
whole‐exome and whole‐genome sequencing, computational tools are needed to explore …

Voltage gated calcium channels (VGCCs) regulate the influx of calcium ions in many cell
types, but our lack of knowledge about the plethora of VGCC splice variants remains a gap in …