[PDF][PDF] Severe COVID-19 is marked by a dysregulated myeloid cell compartment

…, D Wendisch, M Grasshoff, TS Kapellos, M Beckstette… - Cell, 2020 - cell.com
Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract infection, however,
a subset of patients progress to severe disease and respiratory failure. The mechanism …

[HTML][HTML] Critical assessment of metagenome interpretation—a benchmark of metagenomics software

…, D Don Kang, JJ Cook, C Deltel, M Beckstette… - Nature …, 2017 - nature.com
Methods for assembly, taxonomic profiling and binning are key to interpreting metagenome
data, but a lack of consensus about benchmarking complicates performance assessment. …

[HTML][HTML] Foxp3+ T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation

…, P Mamareli, U Lauer, U Hoffmann, M Beckstette… - Mucosal …, 2016 - nature.com
Foxp3+ T cells expressing RORγt represent a stable regulatory T-cell effector lineage with
enhanced suppressive capacity during intestinal inflammation | Mucosal Immunology Skip to …

Tissue dual RNA-seq allows fast discovery of infection-specific functions and riboregulators shaping host–pathogen transcriptomes

AM Nuss, M Beckstette, M Pimenova… - Proceedings of the …, 2017 - National Acad Sciences
Pathogenic bacteria need to rapidly adjust their virulence and fitness program to prevent
eradication by the host. So far, underlying adaptation processes that drive pathogenesis have …

[HTML][HTML] Fast index based algorithms and software for matching position specific scoring matrices

M Beckstette, R Homann, R Giegerich, S Kurtz - BMC bioinformatics, 2006 - Springer
… We summarize the worst case running time of ESAsearch for preprocessing a PSSM M of
length m, searching with M, and reporting all matches with their match scores, as …

[HTML][HTML] Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes

…, M Pasztoi, M Zou, C Wiechers, M Beckstette… - Nature …, 2018 - nature.com
Gut-draining mesenteric lymph nodes (mLNs) are important for inducing peripheral tolerance
towards food and commensal antigens by providing an optimal microenvironment for de …

[HTML][HTML] Reprogramming of Yersinia from Virulent to Persistent Mode Revealed by Complex In Vivo RNA-seq Analysis

…, A Fahlgren, M Huss, AK Heroven, M Beckstette… - PLoS …, 2015 - journals.plos.org
We recently found that Yersinia pseudotuberculosis can be used as a model of persistent
bacterial infections. We performed in vivo RNA-seq of bacteria in small cecal tissue biopsies at …

[HTML][HTML] The alarmones (p)ppGpp are part of the heat shock response of Bacillus subtilis

…, CK Frese, W Steinchen, AM Nuss, M Beckstette… - PLoS …, 2020 - journals.plos.org
Bacillus subtilis cells are well suited to study how bacteria sense and adapt to proteotoxic
stress such as heat, since temperature fluctuations are a major challenge to soil-dwelling …

[HTML][HTML] Transcriptomic Profiling of Yersinia pseudotuberculosis Reveals Reprogramming of the Crp Regulon by Temperature and Uncovers Crp as a Master …

…, J Reinkensmeier, M Jarek, M Beckstette… - PLoS …, 2015 - journals.plos.org
One hallmark of pathogenic yersiniae is their ability to rapidly adjust their life-style and
pathogenesis upon host entry. In order to capture the range, magnitude and complexity of the …

[HTML][HTML] Iron Regulation in Clostridioides difficile

…, AM Michel, C Lassek, AM Nuss, M Beckstette… - Frontiers in …, 2018 - frontiersin.org
The response to iron limitation of several bacteria is regulated by the ferric uptake regulator (Fur).
The Fur-regulated transcriptional, translational and metabolic networks of the Gram-…