Tractography based on non-invasive diffusion imaging is central to the study of human brain
connectivity. To date, the approach has not been systematically validated in ground truth …

The brain operates through the synaptic interaction of distant neurons within flexible, often
heterogeneous, distributed systems. Histological studies have detailed the connections …

Investigative studies of white matter (WM) brain structures using diffusion MRI (dMRI)
tractography frequently require manual WM bundle segmentation, often called “virtual dissection.” …

Diffusion MRI fiber tractography is widely used to probe the structural connectivity of the brain,
with a range of applications in both clinical and basic neuroscience. Despite widespread …

… Example 1, at 30 years and a BMI of 25 kg/m 2 , shows sNfL of 9·5 pg/mL (95th percentile)
and Z score of more than 1·5 (exact value 1·64, as calculated by the sNfL app), and the …

White matter bundle segmentation using diffusion MRI fiber tractography has become the
method of choice to identify white matter fiber pathways in vivo in human brains. However, like …

Importance The mechanisms driving neurodegeneration and brain atrophy in relapsing
multiple sclerosis (RMS) are not completely understood. Objective To determine whether …

Objectives Neuropathological studies have shown that multiple sclerosis (MS) lesions are
heterogeneous in terms of myelin/axon damage and repair as well as iron content. However, it …

… (M and N) MWF and NDI were not different between RRMS and PMS. (O) NDI-MWF scatter
… (M and N) MWF and NDI were not different between RRMS and PMS. (O) NDI-MWF scatter …

Importance There is a lack of validated biomarkers for disability progression independent of
relapse activity (PIRA) in multiple sclerosis (MS). Objective To determine how serum glial …